Evidence map›Paper›PMID 36159593›Full record

ArticleMolecular therapy. Nucleic acids2022

FASTAptameR 2.0: A web tool for combinatorial sequence selections.

Skyler T Kramer, Paige R Gruenke, Khalid K Alam, Dong Xu, Donald H Burke

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. NAR cancer · 2026
    Article
  2. Honeydew: A Fluorescent Aptamer for Low-Cost Azo Food Dyes.Chembiochem : a European journal of chemical biology · 2026
    Article
  3. A GTP synthase ribozyme with increased GTP turnover.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Aptamers in Drug Delivery Development.Materials today (Kidlington, England) · 2025
    Article
  10. DNA aptamer AptScientific reports · 2025
    Article
  11. Article
  12. Article
  13. Rapid discovery of functional RNA domains.Nucleic acids research · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Skyler T KramerMU Institute for Data Science and Informatics, University of Missouri, Columbia, MO, USA.
Paige R GruenkeBond Life Sciences Center, University of Missouri, Columbia, MO, USA.
Khalid K AlamStemloop, Inc., Evanston, IL 60201, USA.
Dong XuMU Institute for Data Science and Informatics, University of Missouri, Columbia, MO, USA.
Donald H BurkeBond Life Sciences Center, University of Missouri, Columbia, MO, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combinatorial selections are powerful strategies for identifying biopolymers with specific biological, biomedical, or chemical characteristics. Unfortunately, most available software tools for high-throughput sequencing analysis have high entrance barriers for many users because they require extensive programming expertise. FASTAptameR 2.0 is an R-based reimplementation of FASTAptamer designed to minimize this barrier while maintaining the ability to answer complex sequence-level and population-level questions. This open-source toolkit features a user-friendly web tool, interactive graphics, up to 100 times faster clustering, an expanded module set, and an extensive user guide. FASTAptameR 2.0 accepts diverse input polymer types and can be applied to any sequence-encoded selection.

Indexed as

aptamercombinatorial selectiondirected evolutionMT: BioinformaticsNext-generation sequencingphage displayribozymeSELEXsequence analysissynthetic biology

Identifiers

PMID36159593
PMCPMC9464650

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.