Evidence map›Paper›PMID 36159581›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2022

Antiulcerogenic and Antibacterial Effects of Chitosan Derivatives on Experimental Gastric Ulcers in Rats.

Leudimar Aires Pereira, Luizângela da Silva Reis, Anderson Nogueira Mendes, Hélio de Barros Fernandes, Daniel Dias Rufino Arcanjo, Adalberto Fortes Rodrigues Júnior, Janete Martins Sousa, Humberto Medeiros Barreto, Jailson de Araújo Santos, Josy Anteveli Osajima and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Protective Effect of the Phycobiliproteins fromPlants (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Leudimar Aires PereiraInterdisciplinary Laboratory of Advanced Materials, Postgraduate Program in Materials Science, Federal University of Piauí, CEP: 64049-550, Teresina, Piauí, Brazil.ORCID https://orcid.org/0000-0002-8594-1613
Luizângela da Silva ReisLaboratory of Biology, Department of Biology, Universidade Federal do Piauí, 64800-000, Floriano, Piauí, Brazil.ORCID https://orcid.org/0000-0002-7955-887X
Anderson Nogueira MendesLaboratory of Innovation in Science and Technology, Department of Biophysics and Physiology, Federal University of Piauí, CEP: 64049-550, Teresina, Piauí, Brazil.ORCID https://orcid.org/0000-0002-9778-3667
Hélio de Barros FernandesLaboratory of Innovation in Science and Technology, Department of Biophysics and Physiology, Federal University of Piauí, CEP: 64049-550, Teresina, Piauí, Brazil.ORCID https://orcid.org/0000-0002-1803-5661
Daniel Dias Rufino ArcanjoLaboratory of Innovation in Science and Technology, Department of Biophysics and Physiology, Federal University of Piauí, CEP: 64049-550, Teresina, Piauí, Brazil.ORCID https://orcid.org/0000-0001-7021-2744
Adalberto Fortes Rodrigues JúniorMultiprofessional Residence and in Professional Health Areas, Federal University of Piauí, CEP: 64049-550, Teresina, Piauí, Brazil.ORCID https://orcid.org/0000-0001-7319-1811
Janete Martins SousaInterdisciplinary Laboratory of Advanced Materials, Postgraduate Program in Materials Science, Federal University of Piauí, CEP: 64049-550, Teresina, Piauí, Brazil.ORCID https://orcid.org/0000-0001-9799-2859
Humberto Medeiros BarretoLaboratory of Microbiology Research, Department of Parasitology and Microbiology, Federal University of Piauí, CEP: 64049-550, Teresina, Piauí, Brazil.ORCID https://orcid.org/0000-0001-5054-7555
Jailson de Araújo SantosInterdisciplinary Laboratory of Advanced Materials, Postgraduate Program in Materials Science, Federal University of Piauí, CEP: 64049-550, Teresina, Piauí, Brazil.ORCID https://orcid.org/0000-0001-5102-3999
Josy Anteveli OsajimaInterdisciplinary Laboratory of Advanced Materials, Postgraduate Program in Materials Science, Federal University of Piauí, CEP: 64049-550, Teresina, Piauí, Brazil.ORCID https://orcid.org/0000-0001-7089-3244
Edson C Silva FilhoInterdisciplinary Laboratory of Advanced Materials, Postgraduate Program in Materials Science, Federal University of Piauí, CEP: 64049-550, Teresina, Piauí, Brazil.ORCID https://orcid.org/0000-0003-0988-2970

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric ulcer is an injury that develops on the lining of the stomach due to an imbalance between aggressive and defensive agents. Chitosan derivatives demonstrate promising biological activities in accelerating the healing activity of gastric lesions. Thus, this study aimed at investigating the healing activity of gastric lesion, induced by acetic acid (80%), of the chitosan derivative with acetylacetone (Cac) modified with ethylenediamine (Cacen) or diethylenetriamine (Cacdien). The biological activity was determined based on cytotoxicity, antibacterial activity, and gastroprotective activities. The results showed no significant difference in the cytotoxicity, a better antibacterial activity against

Identifiers

PMID36159581
PMCPMC9507741

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.