ArticleWorld journal of clinical cases2022
Distinctive clinical features of spontaneous pneumoperitoneum in neonates: A retrospective analysis.
Article in World journal of clinical cases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Idiopathic pneumoperitoneum, a possible complication of pure oxygen administration in a neonate with laryngomalacia: a case report.International journal of surgery case reports · 2026Article
- Idiopathic pneumoperitoneum in infants: A management dilemma and a literature review.Radiology case reports · 2025Article
- Conservative management in a spontaneous pneumoperitoneum post breast augmentation and abdominoplasty: a rare case report.Journal of surgical case reports · 2025Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSpontaneous pneumoperitoneum (SP) without gastrointestinal perforation rarely occurs in neonates, with most SP cases being idiopathic. Although SP usually follows a benign clinical course with favorable prognosis, it can become life-threatening in certain situations. In these cases, urgent surgical intervention may be required. Therefore, it may be difficult to decide when or how to perform prompt interventions.
aimTo demonstrate the distinct clinical features of SP to guide appropriate management by comparing characteristics between SP and typical pneumoperitoneum secondary to gastrointestinal perforation.
methodsWe retrospectively reviewed electronic medical records and identified 37 neonates with radiological evidence of pneumoperitoneum who were treated at our institution. Clinical variables were compared between neonates with SP without gastrointestinal perforation (Group A) and those with pneumoperitoneum secondary to gastrointestinal perforation (Group B). Clinical variables between groups were compared using Student's t-test and the chi-square test. The risk factors related to mortality were examined using multi-logistic regression analysis.
resultsGroup A comprised 35.1% (13/37) of the patients. The frequency of persistent pulmonary hypertension (53.8%) and pneumothorax (46.2%) before the development of pneumoperitoneum was significantly higher in group A than in group B (
conclusionThis study identified a higher mortality rate in patients with SP than that described in previous reports. Neonates with SP were more likely to have thrombocytopenia, pneumothorax, and persistent pulmonary hypertension. Prematurity was the most significant factor affecting mortality.
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