Evidence map›Paper›PMID 36159445›Full record

ArticleKidney international reports2022

Absence of Mortality Differences Between the First and Second COVID-19 Waves in Kidney Transplant Recipients.

Bastien Berger, Marc Hazzan, Nassim Kamar, Hélène Francois, Marie Matignon, Clarisse Greze, Philippe Gatault, Luc Frimat, Pierre F Westeel, Valentin Goutaudier and 22 more

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 20 institutions in 1 country.

Bastien BergerDepartment of Transplantation, Nephrology and Clinical Immunology, Edouard Herriot Hospital, Hospices civils de Lyon, Lyon, France.
Marc HazzanDepartment of Nephrology and Transplantation, University of Lille, Lille, France.
Nassim KamarDepartment of Nephrology and Transplantation, University of Toulouse, Toulouse, France.
Hélène FrancoisDepartment of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Paris, Hôpital Tenon, Paris, France.
Marie MatignonDepartment of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Paris, Institut Francilien de Recherche en Néphrologie et Transplantation IFRNT, Groupe Hospitalier Henri-Mondor/Albert-Chenevier, Université Paris-Est-Créteil, Département Hospitalo-Universitaire, Virus-Immunité-Cancer, Institut Mondor de Recherche Biomédicale, Equipe 21, INSERM U 955, Créteil, France.
Clarisse GrezeDepartment of Nephrology and Transplantation, Hôpital Bichat, Paris, France.
Philippe GataultDepartment of Nephrology and Transplantation, University of Tours, Tours, France.
Luc FrimatDepartment of Nephrology, University of Lorraine, CHRU-Nancy, Vandoeuvre, France, INSERM CIC-EC CIE6, Nancy, France.
Pierre F WesteelDepartment of Nephrology and Transplantation, University of Amiens, Amiens, France.
Valentin GoutaudierDepartment of Nephrology and Transplantation, University of Montpellier, Montpellier, France.
Renaud SnanoudjNephrology and Renal Transplantation Department, Hôpital Foch, Paris, France.
Charlotte ColosioDepartment of Nephrology and Transplantation, University of Reims, Reims, France.
Antoine SicardService de Néphrologie-Dialyse-Transplantation, Hôpital Pasteur 2, CHU de Nice, Unité de Recherche Clinique Côte d'Azur, Université Côte d'Azur, Nice, France.
Dominique BertrandDepartment of Nephrology and Transplantation, University of Rouen, Rouen, France.
Christiane MoussonDepartment of Nephrology and Transplantation, University of Dijon, Dijon, France.
Jamal BamoulidDepartment of Nephrology, University of Besançon, Besançon, France.
Antoine ThierryDepartment of Nephrology and Transplantation, University of Poitiers, Poitiers, France.
Dany AnglicheauService de Néphrologie et Transplantation Adultes, Hôpital Universitaire Necker- APHP Centre-Université de Paris INEM INSERM U 1151 - CNRS UMR 8253, Paris, France.
Lionel CouziService de Néphrologie-Transplantation-Dialyse-Aphérèse, Hôpital Pellegrin, CHU de Bordeaux Pellegrin, Unité Mixte de Recherche "ImmunoConcEpT" 5164 - Université de Bordeaux, Bordeaux, France.
Jonathan M ChemounyUniversity of Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, CIC-P 1414, Rennes, France.
Agnes DuveauDepartment of Nephrology and Transplantation, University of Angers, Angers, France.
Valerie MoalCentre de Néphrologie et Transplantation Rénale, Aix Marseille Université, Hôpitaux Universitaires de Marseille, Hôpital Conception, Marseille, France.
Yannick Le MeurDepartment of Nephrology, CHU de Brest, UMR1227, Lymphocytes B et Autoimmunité, Université de Brest, Inserm, Labex IGO, Brest, France.
Gilles BlanchoDepartment of Nephrology and Transplantation, Centre Hospitalier Universitaire de Nantes, Nantes, France.
Jérôme TourretNephrology and Renal Transplantation Department, Assistance Publique-Hôpitaux de Paris, Hôpital de la Pitié Salpétrière, Paris, France.
Paolo MalvezziDepartment of Nephrology, University of Grenoble, Grenoble, France.
Christophe MariatDepartment of Nephrology and Transplantation, University of St Etienne, St Etienne, France.
Jean-Philippe RerolleDepartment of Nephrology and Transplantation, University of Limoges, Limoges, France.
Nicolas BouvierDepartment of Nephrology and Transplantation, University of Caen, Caen, France.
Sophie CaillardDepartment of Nephrology and Transplantation, Strasbourg University Hospital, Strasbourg, France.
Olivier ThaunatDepartment of Transplantation, Nephrology and Clinical Immunology, Edouard Herriot Hospital, Hospices civils de Lyon, Lyon, France.
French Solid Organ Transplant (SOT) COVID Registry
Inserm · FRUniversité Claude Bernard Lyon 1 · FRHôpital Edouard Herriot · FRSorbonne Université · FRAix-Marseille Université · FRCentre Hospitalier Universitaire Amiens-Picardie · FRCentre Hospitalier Universitaire de Besançon · FRCentre Hospitalier Universitaire de Nantes · FRCentre Hospitalier Universitaire de Nice · FRCentre Hospitalier Universitaire de Reims · FRCentre Hospitalier Universitaire de Rouen · FRHôpital Foch · FRHôpital Necker-Enfants Malades · FRHospices Civils de Lyon · FRUniversité d'Angers · FRUniversité de Bordeaux · FRUniversité de Bourgogne · FRUniversité de Lille · FRUniversité de Montpellier · FRUniversité de Poitiers · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: SARS-CoV-2 pandemic evolved in 2 consecutive waves during 2020. Improvements in the management of COVID-19 led to a reduction in mortality rates among hospitalized patients during the second wave. Whether this progress benefited kidney transplant recipients (KTRs), a population particularly vulnerable to severe COVID-19, remained unclear. Methods: In France, 957 KTRs were hospitalized for COVID-19 in 2020 and their data were prospectively collected into the French Solid Organ Transplant (SOT) COVID registry. The presentation, management, and outcomes of the 359 KTRs diagnosed during the first wave were compared to those of the 598 of the second wave. Results: Baseline comorbidities were similar between KTRs of the 2 waves. Maintenance immunosuppression was reduced in most patients but withdrawal of antimetabolite (73.7% vs. 58.4%, Conclusion: We conclude that changing of therapeutic trends during 2020 did not reduce COVID-19 related mortality among KTRs. Our data indirectly support the importance of vaccination and neutralizing monoclonal anti-SARS-CoV-2 antibodies to protect KTRS from severe COVID-19.

Indexed as

COVID-19SARS-CoV-2transplantation

Identifiers

PMID36159445
PMCPMC9489985
OpenAlexW4297253554

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.