ArticleFrontiers in integrative neuroscience2022
Pain assessment during physiotherapy and noxious stimuli in patients with disorders of consciousness: A preliminary study.
Article in Frontiers in integrative neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Trends and Research Frontiers in Mammalian Target of Rapamycin and Alzheimer's Disease.Molecular neurobiology · 2026Review
- Reliability and Validation Study of the Spanish Translation of the Nociception Coma Scale-Revised-Adapted for Intubated Patients (NCS-R-I).Nursing reports (Pavia, Italy) · 2025Article
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7 authors.
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Abstract
Objectives: The primary purpose of this study is to determine whether patients with disorders of consciousness (DOC) (unresponsive wakefulness syndrome, UWS; minimally conscious state, MCS) experience pain during physiotherapy and noxious stimuli in a larger patient population. Materials and methods: The patients' level of consciousness was measured with the Coma Recovery Scale-Revised (CRS-R). Additionally, the Nociception Coma Scale-revised (NCS-R) was used to assess their pain response. The NCS-R total scores between UWS and MCS at baseline, physiotherapy and noxious stimulus were compared using the Mann-Whitney U test (Wilcoxon rank-sum test) and the Kruskal-Wallis H test with Bonferroni correction. Results: The study enrolled 93 participants. There was a statistically significant difference in NCS-R total scores between the three conditions ( Conclusion: Physiotherapy improved the activity responsiveness of DOC patients, and patients experienced less potential pain. However, some DOC patients, especially MCS patients, perceived pain under the noxious stimuli.
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