Evidence map›Paper›PMID 36159061›Full record

ArticleDental research journal2022

Evaluation of Epstein-Barr virus expression in oral squamous cell carcinomas.

Saeedeh Khalesi, Laleh Maleki, Farzad Ghapani

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Dental research journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Saeedeh KhalesiDental Materials Research Center, Department of Oral and Maxillofacial Pathology, Dental School. Isfahan University of Medical Sciences, Isfahan, Iran.
Laleh MalekiDepartment of Oral and Maxillofacial Pathology, Dental Research Center, Dental School, Isfahan University of Medical Science, Isfahan, Iran.
Farzad GhapaniDepartment of Oral and Maxillofacial Pathology, Dental Students' Research Committee, Dental School, Isfahan University of Medical Sciences, Isfahan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Oral squamous cell carcinoma (OSCC) is one of the most common cancers. Epstein-Barr virus (EBV) has been related to throat-esophageal and gastric cancers. The aim of this study was to evaluate the prevalence of EBV in OSCC. Materials and Methods: This descriptive-analytical cross-sectional study was performed on 48 samples recorded in the archives of the Oral Pathology Department of Isfahan Dental School with definitive diagnosis of OSCCs prepared by excisional biopsy. Samples were selected in different age groups, locations, and genders. The grade of the tumor malignancy was determined based on Annreroth's classification. The EBV expression was determined by immunohistochemical (IHC) staining. The data were entered into SPSS software and statistically analyzed by Results: IHC staining for EBV was positive in 25 samples (52%). There was no significant relationship between EBV expression and mean age, gender, clinical feature, and grade of tumor differentiation ( Conclusion: EBV expression was observed in most of the OSCCs, especially in poorly differentiated tumors. The pathogenesis of OSCCs may be related with EBV. OSCCs in buccal mucosa and floor of the mouth have more frequently of EBV expression. Future studies on the mechanisms of EBV and their role in OSCC are required with larger sample sizes.

Indexed as

Epstein–Barr virusoral cancersquamous cell carcinoma

Identifiers

PMID36159061
PMCPMC9490253

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.