Evidence map›Paper›PMID 36158910›Full record

ReviewWorld journal of hepatology2022

Small extracellular vesicles and liver diseases: From diagnosis to therapy.

Atsunori Tsuchiya, Kazuki Natsui, Yui Ishii, Yohei Koseki, Nobutaka Takeda, Kei Tomiyoshi, Fusako Yamazaki, Yuki Yoshida, Shuji Terai

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Atsunori TsuchiyaDivision of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, Niigata 951-8510, Japan. atsunori@med.niigata-u.ac.jp.
Kazuki NatsuiDepartment of Gastroenterology and Hepatology, Niigata University, Niigata 951-8510, Japan.
Yui IshiiDepartment of Gastroenterology and Hepatology, Niigata University, Niigata 951-8510, Japan.
Yohei KosekiDepartment of Gastroenterology and Hepatology, Niigata University, Niigata 951-8510, Japan.
Nobutaka TakedaDepartment of Gastroenterology and Hepatology, Niigata University, Niigata 951-8510, Japan.
Kei TomiyoshiDepartment of Gastroenterology and Hepatology, Niigata University, Niigata 951-8510, Japan.
Fusako YamazakiDepartment of Gastroenterology and Hepatology, Niigata University, Niigata 951-8510, Japan.
Yuki YoshidaDepartment of Gastroenterology and Hepatology, Niigata University, Niigata 951-8510, Japan.
Shuji TeraiDepartment of Gastroenterology and Hepatology, Niigata University, Niigata 951-8510, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs), especially small EVs (sEVs) derived from liver cells, have been the focus of much attention in the normal physiology and pathogenesis of various diseases affecting the liver. sEVs are approximately 100 nm in size, enclosed within lipid bilayers, and are very stable. The lipids, proteins, and nucleic acids, including miRNAs, contained within these vesicles are known to play important roles in intercellular communication. This mini-review summarizes the application of sEVs. First, liver diseases and the related diagnostic markers are described, and the current active status of miRNA research in diagnosis of hepatocellular carcinoma (HCC) is reported. Second, the biodistribution and pharmacokinetics of sEVs are described, and the liver is highlighted as the organ with the highest accumulation of sEVs. Third, the relationship between sEVs and the pathogenesis of liver disorders is described with emphesis on the current active status of miRNA research in HCC recurrence and survival. Finally, the possibility of future therapy using sEVs from mesenchymal stem (stromal) cells for cirrhosis and other diseases is described.

Indexed as

cirrhosisHepatocellular carcinomaLiverMesenchymal stem cellsSmall extracellular vesicles

Identifiers

PMID36158910
PMCPMC9376785

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.