Evidence map›Paper›PMID 36158889›Full record

ArticleBioMed research international2022

Fetal Fibronectin as a Predictor of Preterm Delivery: A Nigerian Cohort Study.

Cyril C Ikeoha, Chidebe C Anikwe, Osita S Umeononihu, Bartholomew C Okorochukwu, Johnbosco E Mamah, George U Eleje, Chukwuemeka O Ezeama, Basil I Nwokoye, Chigozie F Okoroafor, Ikechukwu S Ugwoke

Abstract read
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The FemTech revolution: Unlocking the potential of new technology for optimizing pregnancy outcomes in low- and middle-income countries and remote areas.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cyril C IkeohaDepartment of Obstetrics & Gynaecology, Alex Ekwueme Federal University Teaching Hospital Abakaliki, P.M. B 102 Abakaliki, Ebonyi state, West Africa, Nigeria.ORCID https://orcid.org/0000-0003-2844-3244
Chidebe C AnikweDepartment of Obstetrics & Gynaecology, Alex Ekwueme Federal University Teaching Hospital Abakaliki, P.M. B 102 Abakaliki, Ebonyi state, West Africa, Nigeria.ORCID https://orcid.org/0000-0002-3730-621X
Osita S UmeononihuDepartment of Obstetrics & Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, P.M.B 5025 Nnewi, Anambra state, West Africa, Nigeria.ORCID https://orcid.org/0000-0003-1636-3845
Bartholomew C OkorochukwuDepartment of Obstetrics and Gynecology, Federal Medical Centre Owerri, P.O. Box 1010, Owerri, Imo State, Nigeria.
Johnbosco E MamahDepartment of Obstetrics & Gynaecology, Alex Ekwueme Federal University Teaching Hospital Abakaliki, P.M. B 102 Abakaliki, Ebonyi state, West Africa, Nigeria.
George U ElejeDepartment of Obstetrics & Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, P.M.B 5025 Nnewi, Anambra state, West Africa, Nigeria.ORCID https://orcid.org/0000-0002-0390-2152
Chukwuemeka O EzeamaDepartment of Obstetrics & Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, P.M.B 5025 Nnewi, Anambra state, West Africa, Nigeria.ORCID https://orcid.org/0000-0003-4499-269X
Basil I NwokoyeDepartment of Obstetrics & Gynaecology, Alex Ekwueme Federal University Teaching Hospital Abakaliki, P.M. B 102 Abakaliki, Ebonyi state, West Africa, Nigeria.
Chigozie F OkoroaforDepartment of Obstetrics & Gynaecology, Alex Ekwueme Federal University Teaching Hospital Abakaliki, P.M. B 102 Abakaliki, Ebonyi state, West Africa, Nigeria.
Ikechukwu S UgwokeDepartment of Obstetrics & Gynaecology, Alex Ekwueme Federal University Teaching Hospital Abakaliki, P.M. B 102 Abakaliki, Ebonyi state, West Africa, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fetal fibronectin is a useful biomarker in the diagnosis and management of preterm labour. Objectives: To evaluate the relationship between cervical fetal fibronectin and preterm delivery and the association between cervical fetal fibronectin level and gestational age at delivery. Materials and Methods: A prospective cohort study was performed in a tertiary hospital in Nigeria, involving equal number of pregnant women with (96) and without (96) preterm labour. Fetal fibronectin assay was done using solid-phase immunogold assay. The data were analysed using IBM SPSS version 24. Descriptive and inferential statistical analyses were done. The level of significance was Results: Less than half (47.9%) of the women in the study group had preterm delivery while 13.09% of the women in the control group delivered preterm. Fetal fibronectin test had a sensitivity, specificity, positive predictive value and negative predictive value of 78%, 86.5%, 71.9%, and 89.0%, respectively, a positive likelihood ratio and negative likelihood ratio of 5.76(95% CI, 3.67 - 9.64) and 0.26(95% CI, 0.16 - 0.41), respectively. Conclusion: The findings in our study value of fetal fibronectin in predicting preterm delivery. Its use will support less intervention for patients with negative results.

Indexed as

Obstetric Labor, PrematurePremature BirthBiomarkersCervix UteriCohort StudiesEnzyme-Linked Immunosorbent AssayFemaleFibronectinsHumansInfant, NewbornNigeriaPredictive Value of TestsPregnancyProspective StudiesSensitivity and SpecificityBiomarkersFibronectins

Identifiers

PMID36158889
PMCPMC9499784

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.