Evidence map›Paper›PMID 36158877›Full record

ArticleBioMed research international2022

Homeobox B9 Promotes the Progression of Hepatocellular Carcinoma via TGF-

Lizhi Bai, Pan Ge, Yanni Zhang, Yi Song, Rong Xing, Dangxia Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lizhi BaiDepartment of Pathology, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Pan GeDepartment of Pathology, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Yanni ZhangDepartment of Emergency, Zhongshan Hospital of Dalian University, Dalian, China.
Yi SongDepartment of Emergency, Zhongshan Hospital of Dalian University, Dalian, China.
Rong XingDepartment of Pathology and Pathophysiology, Dalian Medical University, Dalian, China.
Dangxia ZhouDepartment of Pathology, Health Science Center, Xi'an Jiaotong University, Xi'an, China.ORCID https://orcid.org/0000-0001-9775-8077

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Homeobox B9 (HOXB9), a homeodomain-containing transcription factor, may play a role in hepatocellular carcinoma (HCC) progression. However, the exact mechanisms underlying its action remain unclear. Results: HOXB9 expression was significantly increased in HCC tissues and cell lines. Patients with higher HOXB9 levels were associated with poor prognosis. Overexpression of HOXB9 in BEL-7405 cells promoted proliferation, migration, and invasion, whereas knockdown of HOXB9 in HepG2 cells significantly reduced cell proliferation, migration, and invasion abilities. Mechanically, a positive correlation was found between HOXB9 expression and transforming growth factor- Conclusions: These findings validated that HOXB9 promoted proliferation, migration, and invasion in HCC cells by stimulating the TGF-

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAnimalsBiomarkersCell Line, TumorCell MovementCell ProliferationExtracellular Signal-Regulated MAP KinasesGene Expression Regulation, NeoplasticGenes, HomeoboxHomeodomain ProteinsHumansMAP Kinase Signaling SystemMiceSignal TransductionTranscription FactorsBiomarkersExtracellular Signal-Regulated MAP KinasesHomeodomain ProteinsHOXB9 protein, humanTranscription FactorsTransforming Growth Factor beta1

Identifiers

PMID36158877
PMCPMC9507699

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.