ArticleFrontiers in cardiovascular medicine2022
Association between coronary plaque volume and myocardial ischemia detected by dynamic perfusion CT imaging.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Diffusely impaired myocardial perfusion in patients with suspected coronary artery disease: Clinical utility of relative perfusion.Clinical physiology and functional imaging · 2026Article
- Coronary Computed Tomography Angiography Atherosclerotic Plaque Volume as A Predictor of Myocardial Blood Flow Impairment in Non-Obstructive Coronary Artery Disease.Reviews in cardiovascular medicine · 2025Article
- Impact of technical, patient-related and measurement variables on serial Hounsfield unit-based quantitative coronary plaque analysis in computed tomography: time for a new chapter.European heart journal. Imaging methods and practice · 2025Review
- The role of coronary artery calcium scoring in the prediction of coronary artery disease based on non-contrast non-cardiac chest CT scans in airline pilots.Frontiers in cardiovascular medicine · 2025Article
- Computed tomography myocardial perfusion imaging to detect myocardial ischemia in patients with anxiety and obstructive coronary heart disease post-exposure to mental stressors.Scientific reports · 2024Article
- Dynamic Perfusion Computed Tomography for the Assessment of Concomitant Coronary Artery Disease in Patients with a History of Percutaneous Transluminal Angioplasty for Chronic Limb-Threatening Ischemia-A Pilot Study.Journal of cardiovascular development and disease · 2023Article
- Non-Contrast and Contrast-Enhanced Cardiac Computed Tomography Imaging in the Diagnostic and Prognostic Evaluation of Coronary Artery Disease.Diagnostics (Basel, Switzerland) · 2023Review
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Authors and funding
10 authors.
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Abstract
Introduction: We aimed to evaluate the relationship between quantitative plaque metrics derived from coronary CT angiography (CTA) and segmental myocardial ischemia using dynamic perfusion CT (DPCT). Methods: In a prospective single-center study, patients with > 30% stenosis on rest CTA underwent regadenoson stress DPCT. 480 myocardium segments of 30 patients were analyzed. Quantitative plaque assessment included total plaque volume (PV), area stenosis, and remodeling index (RI). High-risk plaque (HRP) was defined as low-attenuation plaque burden > 4% or RI > 1.1. Absolute myocardial blood flow (MBF) and relative MBF (MBFi: MBF/75th percentile of all MBF values) were quantified. Linear and logistic mixed models correcting for intra-patient clustering and clinical factors were used to evaluate the association between total PV, area stenosis, HRP and MBF or myocardial ischemia (MBF < 101 ml/100 g/min). Results: Median MBF and MBFi were 111 ml/100 g/min and 0.94, respectively. The number of ischemic segments were 164/480 (34.2%). Total PV of all feeding vessels of a given myocardial territory differed significantly between ischemic and non-ischemic myocardial segments ( Conclusion: Total PV was independently associated with myocardial ischemia based on MBF, while area stenosis and HRP were not.
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