Evidence map›Paper›PMID 36158636›Full record

ArticleIEEE transactions on knowledge and data engineering2022

VERTICOX: Vertically Distributed Cox Proportional Hazards Model Using the Alternating Direction Method of Multipliers.

Wenrui Dai, Xiaoqian Jiang, Luca Bonomi, Yong Li, Hongkai Xiong, Lucila Ohno-Machado

Abstract read
In one paragraph

Article in IEEE transactions on knowledge and data engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Private Continuous Survival Analysis with Distributed Multi-Site Data.Proceedings : ... IEEE International Conference on Big Data. IEEE International Conference on Big Data · 2023
    Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenrui DaiSchool of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Xiaoqian JiangSchool of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Luca BonomiUCSD Health Department of Biomedical Informatics, University of California San Diego, La Jolla, CA 92093, USA.
Yong LiDepartment of Electronic Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Hongkai XiongDepartment of Electronic Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Lucila Ohno-MachadoUCSD Health Department of Biomedical Informatics, University of California San Diego, La Jolla, CA 92093, USA.

Funding

Decentralized differentially-private methods for dynamic data release and analysisR01GM118609 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIANG, XIAOQIAN, OHNO-MACHADO, LUCILA · 2017 to 2020
$2.3M
Privacy-preserving methods and tools for handling missing data in distributed health data networksR01GM124111 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LONG, QI · 2017 to 2020
$2.3M
SAFEGENOMES: Strong privacy Assurance For Effective GENOME SharingK99HG010493 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONOMI, LUCA · 2019 to 2020
$222k
NHGRI NIH HHS K99 HG010493NIGMS NIH HHS R01 GM118609NIGMS NIH HHS R01 GM124111
6 · The paper itself

Abstract

The Cox proportional hazards model is a popular semi-parametric model for survival analysis. In this paper, we aim at developing a federated algorithm for the Cox proportional hazards model over vertically partitioned data (i.e., data from the same patient are stored at different institutions). We propose a novel algorithm, namely VERTICOX, to obtain the global model parameters in a distributed fashion based on the Alternating Direction Method of Multipliers (ADMM) framework. The proposed model computes intermediary statistics and exchanges them to calculate the global model without collecting individual patient-level data. We demonstrate that our algorithm achieves equivalent accuracy for the estimation of model parameters and statistics to that of its centralized realization. The proposed algorithm converges linearly under the ADMM framework. Its computational complexity and communication costs are polynomially and linearly associated with the number of subjects, respectively. Experimental results show that VERTICOX can achieve accurate model parameter estimation to support federated survival analysis over vertically distributed data by saving bandwidth and avoiding exchange of information about individual patients. The source code for VERTICOX is available at: https://github.com/daiwenrui/VERTICOX.

Indexed as

alternating direction method of multipliersCox proportional hazards modelFederated survival analysisprivacy protectionvertically partitioned data

Identifiers

PMID36158636
PMCPMC9491599

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.