ArticleFrontiers in aging neuroscience2022
The effects of age and sex on the incidence of multiple step saccades and corrective saccades.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The Role of Prefrontal and Posterior Parietal Cortex in Generating Multiple Step Saccades.Neuroscience bulletin · 2025Article
- Repeatability, reliability, and stability of eye movement measurements in Parkinson's disease, cerebellar ataxia, and healthy adults.Frontiers in neurology · 2025Article
- Age- and Sex-Based Developmental Biomarkers in Eye Movements.Brain sciences · 2024Article
- Multiple step saccades are generated by internal real-time saccadic error correction.Frontiers in neuroscience · 2023Article
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Authors and funding
2 authors.
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Abstract
Objective: Although multiple step saccades (MSS) is occasionally observed in healthy subjects, it is more pronounced in patients with aging-related neurodegenerative diseases, particularly Parkinson's disease (PD). Thus, MSS has been treated as a complementary biomarker for diagnosing PD. Despite the aforementioned knowledge, several questions remain unexplored: (1) How does aging affect MSS? (2) Is there a sex difference in MSS? (3) Are there differences in MSS between vertical and horizontal saccades? (4) Are MSS and corrective saccade (CS) the same behavior? (5) How do age and sex affect CS? The objectives of the present study are to address these questions. Method: Four hundred eighty healthy participants were recruited to perform a visually guided reactive saccade task. Participants were divided into six groups according to their ages. Each group consisted of 40 male and 40 female participants. Eye movements were recorded with infrared eye trackers. Results: The incidence of MSS increased as a function of age, whereas the incidence of CS first increased with age 20-49 and then decreased with age 50-79. The incidences of both MSS and CS did not show sex differences. The incidence of MSS in vertical saccades was significantly higher than that in horizontal saccades, and their difference increased with increasing age, whereas the incidence of CS showed a reversed pattern. Conclusion: Age and saccadic direction affect the occurrences of MSS and CS differently, indicating that MSS and CS are different saccadic behaviors. In addition, measuring saccades could reliably reflect the function of human's brain which is affected by aging.
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