Evidence map›Paper›PMID 36158545›Full record

ArticleFrontiers in aging neuroscience2022

Effect of the ACTN-3 gene polymorphism on functional fitness and executive function of elderly.

Jessica Salles Henrique, Pedro Luiz Garcia Braga, Sandro Soares de Almeida, Nathalia Santanna Petraconi Nunes, Izabelle Dias Benfato, Ricardo Mario Arida, Camila Aparecida Machado de Oliveira, Sérgio Gomes da Silva

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In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jessica Salles HenriqueDepartment of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil.
Pedro Luiz Garcia BragaDepartment of Psychogerontology, Instituto Educatie de Ensino e Pesquisa, Mogi das Cruzes, Brazil.
Sandro Soares de AlmeidaHospital Israelita Albert Einstein, São Paulo, Brazil.
Nathalia Santanna Petraconi NunesDepartment of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil.
Izabelle Dias BenfatoDepartment of Bioscience, Universidade Federal de São Paulo, Campus Baixada Santista, Santos, Brazil.
Ricardo Mario AridaDepartment of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil.
Camila Aparecida Machado de OliveiraDepartment of Bioscience, Universidade Federal de São Paulo, Campus Baixada Santista, Santos, Brazil.
Sérgio Gomes da SilvaDepartment of Research and Extension, Fundação Cristiano Varella, Muriaé, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During aging, physical integrity and cognitive abilities, especially executive function, become compromised, directly influencing the quality of life of the elderly. One good strategy to ensure healthy aging is the practice of physical exercise. Activities to improve aerobic capacity and muscle strength are extremely important in old age. However, some genetic factors can interfere both positively and negatively with these gains. In this context, the polymorphism rs1815739 (R577X) of the α-actinin 3 gene (ACTN-3) is commonly studied and related to muscle phenotype. Thus, the present study aimed to investigate the effect of the ACTN-3 gene polymorphism on the functional fitness (measured by the Senior Fit test) and cognitive capacity (evaluated by the Stroop test) of the elderly (

Indexed as

ACTN-3agingcognitionexecutive functionfunctional fitness

Identifiers

PMID36158545
PMCPMC9501855

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.