ArticleFrontiers in aging neuroscience2022
Frailty and hearing loss: From association to causation.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Association between handgrip strength to Cystatin C ratio and hearing loss: insights from the CHARLS study.Journal of health, population, and nutrition · 2025Article
- Abnormalities of resting-state EEG microstates in older adults with cognitive frailty.GeroScience · 2025Article
- Dietary intake of live microbes and its association with frailty in older adults: a NHANES analysis (1999-2018).BMC geriatrics · 2025Article
- Article
- The relationship between hearing loss and frailty in older adults at risk of cognitive decline: a cross-sectional study.Frontiers in aging · 2025Article
- Hearing loss is not associated with risk of Parkinson's disease: A Mendelian randomization study.Heliyon · 2024Article
- Olfactory decline develops in parallel with frailty in older US adults with obstructive lung diseases.International forum of allergy & rhinology · 2024Article
- Exploration of the causality of frailty index on psoriasis: A Mendelian randomization study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Phthalate Metabolites Were Related to the Risk of High-Frequency Hearing Loss: A Cross-Sectional Study of National Health and Nutrition Examination Survey.Journal of multidisciplinary healthcare · 2024Article
- Assessment of the bidirectional causal association between frailty and depression: A Mendelian randomization study.Journal of cachexia, sarcopenia and muscle · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Background: Observational studies suggest that frailty is associated with hearing loss (HL) but with inconsistent results. This study aims to examine such association and to assess its causality. Materials and methods: The cross-sectional data from the National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression models were used to assess the association between HL and frailty index (FI). Genetic variants associated with the FI and HL were obtained from a large genome-wide association study (GWAS) meta-analysis and UK Biobank GWAS. The inverse variance weighting (IVW) method was used to estimate causal effects. Sensitivity analyses were performed to further validate the robustness of results. Results: In this cross-sectional analysis, results support the possibility that frailty may be associated with a higher risk of developing HL, with self-reported [odds ratio (OR) = 2.813; 95% CI, 2.386, 3.317; Conclusion: Our observational study found that inter-individual differences in frailty were associated with the risk of developing HL. Genetic evidence suggests a potential bidirectional causal association between FI and HL. Furthermore, the potential mechanisms of this association require investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.