ArticleCureus2022
Association of Hypothyroidism With Low Serum Ferritin Levels and Iron-Deficiency Anemia During the First Trimester of Pregnancy.
Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of iron status indicators with thyroid hormone concentrations during pregnancy: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- The association of body mass index and weight waist adjustment index with serum ferritin in a national study of US adults.European journal of medical research · 2023Article
- Maternal Mineral Nutrition Regulates Fetal Genomic Programming in Cattle: A Review.Metabolites · 2023Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background The association between hypothyroidism and iron-deficiency anemia (IDA) in pregnancy is not well established. Hence, this study aimed to investigate the association between hypothyroidism and IDA during the first trimester of pregnancy. Methodology In this study, a total of 144 pregnant women were included. Thyroid-stimulating hormone (TSH), free T4 (FT4), free T3 (FT3), and ferritin were measured. Based on TSH values, pregnant women were divided into the following two groups: euthyroid (n = 74) and hypothyroid (n = 70). Results There was a significant increase in TSH levels and a significant decrease in the levels of FT4, FT3, ferritin, iron, and hemoglobin (Hb) in hypothyroid pregnant women compared to euthyroid pregnant women. The correlation and regression analysis revealed a significant negative association of TSH and a positive association of FT4 with ferritin, iron, and Hb. Conclusions These findings demonstrate the association of hypothyroidism with IDA during the first trimester of pregnancy. Further studies with thyroxine therapy in hypothyroid pregnant women and its impact on IDA will open novel therapeutic approaches in the management of IDA during pregnancy. Further, measurement of serum ferritin during pregnancy may provide valuable information in the diagnosis and management of IDA.
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