Evidence map›Paper›PMID 36158191›Full record

ReviewFrontiers in cell and developmental biology2022

The interplay between physical cues and mechanosensitive ion channels in cancer metastasis.

Kaustav Bera, Alexander Kiepas, Yuqi Zhang, Sean X Sun, Konstantinos Konstantopoulos

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. [Plectin Promotes the Migration of Hepatocellular Carcinoma Cells Through Inducing F-actin Polymerization].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kaustav BeraDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, United States.
Alexander KiepasDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, United States.
Yuqi ZhangDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, United States.
Sean X SunDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, United States.
Konstantinos KonstantopoulosDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, United States.
Johns Hopkins University · US

Funding

The interplay of ion transporters and cytoskeleton in breast cancer migration and metastasisR01CA254193 · NCI · JOHNS HOPKINS UNIVERSITY · PI KONSTANTOPOULOS, KONSTANTINOS, MARTIN, STUART S · 2021 to 2025
$2.7M
Viscotaxis: Novel cell migration mechanisms regulated by microenvironmental viscosityR01CA257647 · NCI · JOHNS HOPKINS UNIVERSITY · PI KONSTANTOPOULOS, KONSTANTINOS · 2021 to 2025
$2.3M
Cell mechanobiology in confinement using an integration of bioengineering, materials systems and in vivo modelsR01GM142175 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KONSTANTOPOULOS, KONSTANTINOS · 2021 to 2024
$1.8M
NCI NIH HHS R01 CA254193NCI NIH HHS R01 CA257647NIGMS NIH HHS R01 GM142175
6 · The paper itself

Abstract

Physical cues have emerged as critical influencers of cell function during physiological processes, like development and organogenesis, and throughout pathological abnormalities, including cancer progression and fibrosis. While ion channels have been implicated in maintaining cellular homeostasis, their cell surface localization often places them among the first few molecules to sense external cues. Mechanosensitive ion channels (MICs) are especially important transducers of physical stimuli into biochemical signals. In this review, we describe how physical cues in the tumor microenvironment are sensed by MICs and contribute to cancer metastasis. First, we highlight mechanical perturbations, by both solid and fluid surroundings typically found in the tumor microenvironment and during critical stages of cancer cell dissemination from the primary tumor. Next, we describe how Piezo1/2 and transient receptor potential (TRP) channels respond to these physical cues to regulate cancer cell behavior during different stages of metastasis. We conclude by proposing alternative mechanisms of MIC activation that work in tandem with cytoskeletal components and other ion channels to bestow cells with the capacity to sense, respond and navigate through the surrounding microenvironment. Collectively, this review provides a perspective for devising treatment strategies against cancer by targeting MICs that sense aberrant physical characteristics during metastasis, the most lethal aspect of cancer.

Indexed as

cancer metastasiscell cytoskeletoncell migrationmechanosensitive (MS) ion channelphysical forces

Identifiers

PMID36158191
PMCPMC9490090
OpenAlexW4297261567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.