ArticleWorld journal of clinical cases2022
Impact of cancer on mortality rates in patients with sepsis: A meta-analysis and meta-regression of current studies.
Article in World journal of clinical cases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Perspective on Lessons Not Learned: From Coley's Toxins to Microbial Drug Delivery, Guidance for Institutional Review Boards (IRBs).International journal of molecular sciences · 2026Review
- Trends in mortality from cancer and sepsis in the United States, 1999 to 2023: An analysis of CDC WONDER data.Medicine · 2026Article
- Risk Factors for Adverse Outcomes in Cancer Patients With Sepsis.Journal of clinical medicine research · 2026Article
- Observational
- The Association Between Central Venous Pressure and Acute Kidney Injury Development in Patients with Septic Shock.Journal of clinical medicine · 2025Article
- Predictors of severe disease in Streptococcus dysgalactiae subsp. equisimilis bacteremia: a population-based study.BMC infectious diseases · 2025Article
- Comprehensive risk factor-based nomogram for predicting one-year mortality in patients with sepsis-associated encephalopathy.Scientific reports · 2024Article
- Risk Factors and Outcomes of Community-Acquired Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Sepsis survivors readmitted within 30 days: outcomes of a single-center retrospective study.Critical care science · 2024Article
- Cancer and sepsis.Clinical science (London, England : 1979) · 2023Article
- Impact of Infection Patterns on the Outcomes of Patients with Hematological Malignancies in Southwest China: A 10-Year Retrospective Case-Control Study.Infection and drug resistance · 2023Article
- An Individualized Nomogram for Predicting Mortality Risk of Septic Shock Patients During Hospitalization: A ten Years Retrospective Analysis.Infection and drug resistance · 2023Article
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2 authors.
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Abstract
backgroundResearch suggests that approximately 6% of adult patients admitted to hospitals in the United States present with sepsis and there has been a minimal change in the incidence of this condition in the last decade. Furthermore, patients with cancer generally have a higher incidence of sepsis due to immunosuppression caused by cancer or its treatment.
aimTo assess if cancer increases the mortality rates in sepsis patients by pooling evidence from contemporary studies.
methodsPubMed, Embase, and Google Scholar databases were searched from January 1, 2001 to December 15, 2021 for studies comparing outcomes of sepsis patients based on the presence of active cancer. Mortality data were pooled using a random-effects model, with the odds ratio (OR) and 95% confidence interval (CI) calculated. Meta-regression was conducted to assess the influence of confounders on mortality rates.
resultsNine studies were included. The meta-analysis demonstrated a non-significant tendency towards increased risk of early mortality (OR = 2.77, 95%CI: 0.88-8.66,
conclusionContemporary evidence indicates that the presence of any cancer in sepsis patients significantly increases the risk of mortality. Scarce data suggest that mortality is equally increased for both solid and hematological cancers. Current evidence is limited by high heterogeneity and there is a need for further studies taking into account several confounding variables to present better evidence.
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