ArticleCase reports in oncology
OPRM1-ROS1 Fusion Detected by Next-Generation Sequencing with Circulating DNA in a Patient with EGFR Mutated Advanced NSCLC: A Case Report.
Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- EZR-ROS1 rearrangement as a novel mechanism of acquired resistance to EGFR-TKIs in NSCLC: a case report and literature review.Frontiers in immunology · 2026Review
- Concomitant epidermal growth factor receptor mutation/c-ros oncogene 1 rearrangement in non-small cell lung cancer: A case report.World journal of clinical oncology · 2024Article
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Authors and funding
3 authors.
Funding
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Abstract
ROS1 comprises a small molecular subset of NSCLC, and several fusion partners have been discovered. Concomitant mutations of EGFR and ROS1 in NSCLC have been occasionally reported, while no clear standard of treatment has been revealed. Here we report a case with metastatic lung adenocarcinoma detected to have EGFR 21 exon L858R mutation at diagnosis, who responded to first-line gefitinib and second-line osimertinib treatment. Next-generation sequencing during the treatment course revealed multiple alterations, including an OPRM1-ROS1 Ointergenic: R36 fusion. We reviewed the related literatures but found no report of this fusion type previously. The application of ctDNA detection results in the finding of new alterations, which need further confirmation.
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