Evidence map›Paper›PMID 36157623›Full record

ArticleNeurology. Clinical practice2022

Adverse Childhood Experiences in Patients With Neurologic Disease.

Adys Mendizabal, Cody L Nathan, Pouya Khankhanian, Marissa Anto, Cynthia Clyburn, Alexandra Acaba-Berrocal, Louise Breen, Nabila Dahodwala

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adys MendizabalDepartment of Neurology (AM), University of California Los Angeles (UCLA); Department of Neurology (CLN), Northwestern University Memorial Hospital, Chicago, IL; Department of Neurology (PK), Kaiser Permanente Walnut Creek Medical Center, Walnut Creek, CA; Department of Neurology (MA), Children's Hospital of Philadelphia (CHOP); Department of Neurology (CC, AA-B, ND), Hospital of the University of Pennsylvania; and Perlman School of Medicine at the University of Pennsylvania (LB), Philadelphia.
Cody L NathanDepartment of Neurology (AM), University of California Los Angeles (UCLA); Department of Neurology (CLN), Northwestern University Memorial Hospital, Chicago, IL; Department of Neurology (PK), Kaiser Permanente Walnut Creek Medical Center, Walnut Creek, CA; Department of Neurology (MA), Children's Hospital of Philadelphia (CHOP); Department of Neurology (CC, AA-B, ND), Hospital of the University of Pennsylvania; and Perlman School of Medicine at the University of Pennsylvania (LB), Philadelphia.
Pouya KhankhanianDepartment of Neurology (AM), University of California Los Angeles (UCLA); Department of Neurology (CLN), Northwestern University Memorial Hospital, Chicago, IL; Department of Neurology (PK), Kaiser Permanente Walnut Creek Medical Center, Walnut Creek, CA; Department of Neurology (MA), Children's Hospital of Philadelphia (CHOP); Department of Neurology (CC, AA-B, ND), Hospital of the University of Pennsylvania; and Perlman School of Medicine at the University of Pennsylvania (LB), Philadelphia.ORCID 0000-0001-8075-4176
Marissa AntoDepartment of Neurology (AM), University of California Los Angeles (UCLA); Department of Neurology (CLN), Northwestern University Memorial Hospital, Chicago, IL; Department of Neurology (PK), Kaiser Permanente Walnut Creek Medical Center, Walnut Creek, CA; Department of Neurology (MA), Children's Hospital of Philadelphia (CHOP); Department of Neurology (CC, AA-B, ND), Hospital of the University of Pennsylvania; and Perlman School of Medicine at the University of Pennsylvania (LB), Philadelphia.ORCID 0000-0001-5923-2285
Cynthia ClyburnDepartment of Neurology (AM), University of California Los Angeles (UCLA); Department of Neurology (CLN), Northwestern University Memorial Hospital, Chicago, IL; Department of Neurology (PK), Kaiser Permanente Walnut Creek Medical Center, Walnut Creek, CA; Department of Neurology (MA), Children's Hospital of Philadelphia (CHOP); Department of Neurology (CC, AA-B, ND), Hospital of the University of Pennsylvania; and Perlman School of Medicine at the University of Pennsylvania (LB), Philadelphia.
Alexandra Acaba-BerrocalDepartment of Neurology (AM), University of California Los Angeles (UCLA); Department of Neurology (CLN), Northwestern University Memorial Hospital, Chicago, IL; Department of Neurology (PK), Kaiser Permanente Walnut Creek Medical Center, Walnut Creek, CA; Department of Neurology (MA), Children's Hospital of Philadelphia (CHOP); Department of Neurology (CC, AA-B, ND), Hospital of the University of Pennsylvania; and Perlman School of Medicine at the University of Pennsylvania (LB), Philadelphia.
Louise BreenDepartment of Neurology (AM), University of California Los Angeles (UCLA); Department of Neurology (CLN), Northwestern University Memorial Hospital, Chicago, IL; Department of Neurology (PK), Kaiser Permanente Walnut Creek Medical Center, Walnut Creek, CA; Department of Neurology (MA), Children's Hospital of Philadelphia (CHOP); Department of Neurology (CC, AA-B, ND), Hospital of the University of Pennsylvania; and Perlman School of Medicine at the University of Pennsylvania (LB), Philadelphia.
Nabila DahodwalaDepartment of Neurology (AM), University of California Los Angeles (UCLA); Department of Neurology (CLN), Northwestern University Memorial Hospital, Chicago, IL; Department of Neurology (PK), Kaiser Permanente Walnut Creek Medical Center, Walnut Creek, CA; Department of Neurology (MA), Children's Hospital of Philadelphia (CHOP); Department of Neurology (CC, AA-B, ND), Hospital of the University of Pennsylvania; and Perlman School of Medicine at the University of Pennsylvania (LB), Philadelphia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: To describe the prevalence of high adverse childhood experiences (ACEs) among neurology outpatients and determine their association with health care utilization rates and comorbid medical and psychiatric disease. Methods: This was a cross-sectional study of adults seen for outpatient neurology follow-up at the University of Pennsylvania. Participants completed the ACE questionnaire and depression/anxiety screenings. Health care utilization metrics (emergency department [ED] visits, hospitalizations, and outpatient calls) were obtained for all participants. High ACE scores were defined as a score of ≥4. The prevalence of high ACE scores in our cohort was compared with US historical controls. Statistical associations were adjusted for age, sex, and race/ethnicity. Results: One hundred ninety-eight patients were enrolled in the study. Neurology patients were more likely to have elevated ACE scores compared with US population estimates (23.7% vs 12.6%, Discussion: Patients with neurologic conditions are more likely to have high ACEs than the US population, which was associated with higher rates of health care utilization, increased number of medical and psychiatric comorbidities, and higher anxiety and depression scores. Addressing ACEs may be a way to improve the health outcomes of patients with neurologic conditions.

Identifiers

PMID36157623
PMCPMC9491504

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.