Evidence map›Paper›PMID 36157546›Full record

SynthesisWorld journal of gastroenterology2022

Recurrence rates after endoscopic resection of large colorectal polyps: A systematic review and meta-analysis.

Carola Rotermund, Roupen Djinbachian, Mahsa Taghiakbari, Markus D Enderle, Axel Eickhoff, Daniel von Renteln

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in World journal of gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06217250 (Hot EMR vs Underwater Cold EMR for Large Colonic Adenomas), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06217250 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Hot EMR vs Underwater Cold EMR for Large Colonic Adenomas (>20 mm): the "CO.W.L." Prospective Randomized Trial

TypeinterventionalSponsorIstituto Clinico HumanitasRan2024 to 2026Enrolled330ConditionsColonic Neoplasms, Colonic Adenoma, Colonic LesionArmsTraditional EMR, the cold snare ("CO"), underwater technique ("W"), and the use of submucosal lift ("L") in both study arms
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  13. Salvage endoscopic resection for perforation site recurrence of colonic polyp.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carola RotermundResearch and Basic Technologies, ERBE Elektromedizin GmbH, Tuebingen 72072, Germany.
Roupen DjinbachianDivision of Internal Medicine, Montreal University Hospital Center, Montreal QC H2X 3E4, Canada.
Mahsa TaghiakbariMontreal University Hospital Research Center, Montreal University Hospital Center, Montreal QC H2X 3E4, Canada.
Markus D EnderleResearch and Basic Technologies, ERBE Elektromedizin GmbH, Tuebingen 72072, Germany.
Axel EickhoffDepartment of Internal Medicine II, Klinikum Hanau, Hanau 63450, Germany.
Daniel von RentelnMontreal University Hospital Research Center, Montreal University Hospital Center, Montreal QC H2X 3E4, Canada. danielrenteln@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComplete polyp resection is the main goal of endoscopic removal of large colonic polyps. Resection techniques have evolved in recent years and endoscopic submucosal dissection (ESD), endoscopic mucosal resection (EMR) with margin ablation, cold snare polypectomy (CSP), cold EMR, and underwater EMR have been introduced. Yet, efficacy of these techniques with regard to local recurrence rates (LRRs)

aimTo analyze LRR of large colonic polyps in a systematic review and meta-analysis.

methodsMEDLINE, EMBASE, EBM Reviews, and CINAHL were searched for prospective studies reporting LRR or incomplete resection rate (IRR) after colonic polypectomy of polyps ≥ 10 mm, published between January 2011 and July 2021. Primary outcome was LRR for polyps ≥ 10 mm.

resultsSix thousand nine hundred and twenty-eight publications were identified, of which 34 prospective studies were included. LRR for polyps ≥ 10 mm at up to 12 mo' follow-up was 11.0% (95%CI, 7.1%-14.8%; 15 studies; 4904 polyps). ESD (1.7%; 95%CI, 0%-3.4%; 3 studies, 221 polyps) and endoscopic mucosal resection with margin ablation (3.3%; 95%CI, 2.2%-4.5%; 2 studies, 947 polyps) significantly reduced LRR

conclusionLRR is significantly lower after ESD or EMR with routine margin ablation; thus, these techniques should be considered standard for endoscopic removal of large colorectal polyps. Other techniques, such as CSP, cold EMR, and underwater EMR require further evaluation in prospective studies before their routine implementation in clinical practice can be recommended.

Indexed as

Colonic PolypsColorectal NeoplasmsEndoscopic Mucosal ResectionColonoscopyHumansMargins of ExcisionProspective StudiesTreatment OutcomeAdenomaColonoscopyColorectal cancerEndoscopic mucosal resectionPolyp

Identifiers

PMID36157546
PMCPMC9367239

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.