Evidence map›Paper›PMID 36157508›Full record

ArticleGenes & diseases2022

Genetic profiles of familial late-onset Alzheimer's disease in China: The Shanghai FLOAD study.

Xin-Yi Xie, Qian-Hua Zhao, Qiang Huang, Eric Dammer, Sheng-di Chen, Ru-Jing Ren, Gang Wang, Alzheimer's Disease Neuroimaging Initiative

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The China Alzheimer Report 2025.General psychiatry · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. E674Q (ShanghaiGenes & diseases · 2024
    Article
  9. Article
  10. Article
  11. Biofluid biomarkers for Alzheimer's disease.Frontiers in aging neuroscience · 2024
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Xin-Yi XieDepartment of Neurology and Institute of Neurology, Ruijin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.
Qian-Hua ZhaoInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, PR China.
Qiang HuangDepartment of Neurology and Institute of Neurology, Ruijin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.
Eric DammerDepartment of Biochemistry, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA.
Sheng-di ChenDepartment of Neurology and Institute of Neurology, Ruijin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.
Ru-Jing RenDepartment of Neurology and Institute of Neurology, Ruijin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.
Gang WangDepartment of Neurology and Institute of Neurology, Ruijin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.
Alzheimer's Disease Neuroimaging Initiative
Shanghai Jiao Tong University · CNEmory University · USFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compared with early-onset familial AD (FAD), the heritability of most familial late-onset Alzheimer's disease (FLOAD) cases still remains unclear. However, there are few reported genetic profiles of FLOAD to date. In the present study, targeted sequencing of selected candidate genes was conducted for each of 90 probands with FLOAD and 101 unrelated matched normal controls among Chinese Han population. Results show a significantly lower rate of mutation in APP and PSENs, and

Indexed as

ACEAlzheimer's diseaseFamilial late-onset Alzheimer's diseaseGeneMutation

Identifiers

PMID36157508
PMCPMC9485165
OpenAlexW3169826059

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.