ArticleFrontiers in endocrinology2022
Placental pathologic lesions associated with stroke in term neonates.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Understanding Pediatric Stroke: Etiology, Diagnosis, and Management in Children Under 15 Years.Cureus · 2026Review
- Enhancing the utility of placental pathology reports for clinical use.Pregnancy (Hoboken, N.J.) · 2025Review
- Placental inflammatory response and association with the severity of neonatal hypoxic ischemic encephalopathy.Early human development · 2025Article
- Placental chronic inflammatory histopathology and fetal growth in a cohort with universal placental examination.Placenta · 2024Article
- Postnatal Cerebral Hemodynamics and Placental Vascular Malperfusion Lesions in Neonates With Congenital Heart Disease.Pediatric neurology · 2024Article
- Regulatory Roles of MicroRNAs in the Pathogenesis of Metabolic Syndrome.Molecular biotechnology · 2024Review
- [A multicenter study of neonatal stroke in Shenzhen, China].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Placental pathology and neonatal morbidity: exploring the impact of gestational age at birth.BMC pregnancy and childbirth · 2024Observational
- Advances in the Diagnosis and Treatment of Pediatric Arterial Ischemic Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Leveraging the placenta to advance neonatal care.Frontiers in pediatrics · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To determine the birth prevalence of perinatal stroke in term born infants at our high-volume delivery center and assess the frequency of both gross and histologic placental pathologies associated with perinatal stroke using the Amsterdam Placental Workshop Group Consensus Statement guidelines and definitions. Study Design: A single-center retrospective cohort study spanning 2010-2020. Results: There were 129,759 live births at Parkland Hospital during the study period and a total of 18 term born infants leading to a birth prevalence of 1 in 6,829 infants. Perinatal risk factors were found in all but one patient, and 74% presented with seizures. Pathologic placental examination was available in 56% of the cohort and only one patient had normal placental examination. Acute histologic chorioamnionitis was described in five placentas (50%) and an additional two had isolated umbilical and/or chorionic plate vasculitis with or without funisitis compared to a rate of 28% with acute inflammation in a Control group. Chronic inflammation in the form of villitis of unknown etiology was described in three of the acutely inflamed placentas and was high-grade in each of those while none of the placentas from our Control group showed evidence of any chronic lesion. Conclusion: Both acute and chronic placental inflammation are common in perinatal stroke; placental examination should be considered an essential component to the diagnostic workup.
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