ArticleFrontiers in surgery2022
Risk factors and management associated with postoperative cerebrospinal fluid leak after endoscopic endonasal surgery for pituitary adenoma.
Article in Frontiers in surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Skull base reconstruction using hydroxyapatite and nasoseptal flap versus nasoseptal flap alone: meta-analysis and systematic review.Scientific reports · 2024Pooled it
- Risk factors of cerebrospinal fluid leakage after neuroendoscopic transsphenoidal pituitary adenoma resection: a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Pedicled Nasoseptal Flap After Endoscopic Endonasal Resection of Skull Base Tumors: A Comparative Meta-Analysis with Other Modalities of Reconstruction.Journal of neurological surgery. Part B, Skull base · 2026Article
- Endoscopic endonasal resection of ectopic suprasellar pituitary neuroendocrine tumors: comparison of intra-stalk and extra-stalk tumors. Illustrative cases.Journal of neurosurgery. Case lessons · 2026Article
- Synthetic polyurethane foam for sphenoid packing after endonasal skull base surgery: propensity-matched trends in cerebrospinal fluid leakage and sphenoid mucosal changes.Neurosurgical review · 2026Observational
- Clinical predictors of postoperative cerebrospinal fluid leakage following endoscopic endonasal surgery for pituitary neuroendocrine tumors: a retrospective cohort study.BMC neurology · 2026Article
- Risk factors and predictive model for postoperative cerebrospinal fluid leakage following endoscopic endonasal pituitary adenoma surgery: a retrospective study focusing on pneumocephalus and sellar floor bony window.Frontiers in endocrinology · 2025Article
- Upright CT-based evaluation of the effects of posture on skull-base reconstruction after endoscopic endonasal surgery.Scientific reports · 2024Article
- Reducing CSF complications by a recycled Hadad's flap combined with autologous mucosa in secondary endoscope transsphenoidal surgery.Frontiers in oncology · 2023Article
- Prediction of intraoperative cerebrospinal fluid leaks in endoscopic endonasal transsphenoidal pituitary surgery based on a deep neural network model trained with MRI images: a pilot study.Frontiers in neuroscience · 2023Article
Corrections and comments
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: To determine risk factors and management for the development of a postoperative cerebrospinal fluid (CSF) leak after an endoscopic endonasal surgery (EES) for pituitary adenomas. Methods: The clinical data of 400 patients who underwent EES for resection of pituitary adenomas from December 2018 to November 2019 in the Department of Neurosurgery of Beijing Tiantan Hospital were retrospectively reviewed. Age, gender, body mass index (BMI), tumor size, Knosp grade, suprasellar extension grade, sellar floor erosion grade, repeated transsphenoidal surgery, intraoperative CSF leak, use of pedicled nasoseptal flap and lumbar drain were collected and analyzed. Results: Postoperative CSF leak occurred in 14 of 400 patients (3.5%). Age, gender, BMI, tumor size, Knosp grade and repeated transsphenoidal surgery were not risk factors for CSF leak. Suprasellar extension grade (≥B 6.0% vs. <B 1.4%; Conclusions: Higher suprasellar extension grade, higher sellar floor erosion grade and intraoperative CSF leak were risk factors for postoperative CSF leak after endoscopic treatment of pituitary adenoma. Strict skull base reconstruction including use of a pedicled nasoseptal flap and perioperative lumbar drainage may avoid postoperative CSF leak.
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