SynthesisTransplant international : official journal of the European Society for Organ Transplantation2022
Physical Effects, Safety and Feasibility of Prehabilitation in Patients Awaiting Orthotopic Liver Transplantation, a Systematic Review.
Synthesis in Transplant international : official journal of the European Society for Organ Transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- The influence of prehabilitation in patients with liver cirrhosis before liver transplantation: a randomized clinical trial.European journal of physical and rehabilitation medicine · 2024Trial
- Preoperative prehabilitation in adults: A concept analysis.International journal of nursing studies advances · 2026Review
- Evaluation and management of primary sclerosing cholangitis patients awaiting liver transplantation.JHEP reports : innovation in hepatology · 2026Review
- Frailty and Early Extubation Independently Influence Postoperative Recovery Following Liver Transplantation-A Retrospective Cohort Study.Journal of transplantation · 2026Article
- Donor-recipient age mismatch and outcomes in liver transplantation: A scientific registry of transplant recipients database analysis.World journal of transplantation · 2025Article
- Nutritional aspects of prehabilitation in adults with cirrhosis awaiting liver transplant.Hepatology (Baltimore, Md.) · 2025Review
- Prediction and management of small-for-size syndrome in living donor liver transplantation.Clinical and molecular hepatology · 2025Review
- Muscle Strength and Cardiovascular Health in MASLD: A Prospective Study.Medicina (Kaunas, Lithuania) · 2025Article
- Feasibility of prehabilitation for patients awaiting total knee arthroplasty; a pilot study.Journal of orthopaedics · 2025Article
- Frailty in liver transplantation: Exploring prescribing exercise as medicine to improve patient outcomes.Liver international : official journal of the International Association for the Study of the Liver · 2024Review
- Sarcopenic obesity in patients awaiting liver transplant: Unique challenges for nutritional recommendations.World journal of transplantation · 2024Review
- Physical activity decreases in patients on the liver transplant waiting list and influences postoperative outcome-a prospective cohort study.Hepatobiliary surgery and nutrition · 2024Article
- Prehabilitation: tertiary prevention matters.The British journal of surgery · 2024Article
- Article
- Frailty in end-stage liver disease: Understanding pathophysiology, tools for assessment, and strategies for management.World journal of gastroenterology · 2023Review
- Preoperative screening and prehabilitation strategies prior to ileocolic resection in patients with Crohn's disease are not incorporated in routine care.International journal of colorectal disease · 2023Article
- From Listing to Recovery: A Review of Nutritional Status Assessment and Management in Liver Transplant Patients.Nutrients · 2023Review
- Predicting a kidney transplant patient's pre-transplant functional status based on information from waitlist registration.Scientific reports · 2023Article
- Therapeutic Physical Exercise Programs in the Context of NASH Cirrhosis and Liver Transplantation: A Systematic Review.Metabolites · 2023Review
- Body mass index affects kidney transplant outcomes: A cohort study over 5 years using a steroid sparing protocol.Frontiers in endocrinology · 2023Observational
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prehabilitation improves surgical outcomes in patients undergoing surgery. However, patients preparing for orthotopic liver transplantation (OLT) are physically "frail" and suffer from comorbidities that generally hamper physical activity. This systematic review aims to evaluate the physical effects, safety and feasibility of prehabilitation in OLT candidates. Relevant articles were searched, in Embase, Web of Science, Cochrane, Medline and Google Scholar, to December 2021. Studies reporting on specified preoperative exercise programs, including adult OLT candidates with end-stage liver disease, with a model for end-stage liver disease (MELD) score ≥12 or Child-Pugh classification B/C, were included. This resulted in 563 potentially eligible studies, out of which eight were selected for inclusion, consisting of 1,094 patients (male sex 68%; mean age 51-61 years; mean MELD score 12-21). Six of the included studies were classified as low-quality by the GRADE system, and three studies had high risk for ineffectiveness of the training program according to the i-CONTENT tool. Significant improvement was observed in VO2 peak, 6-minute walking distance, hand grip strength, liver frailty index and quality of life. Feasibility ranged from an adherence of 38%-90% in unsupervised-to >94% in supervised programs. No serious adverse events were reported. In conclusion, prehabilitation in patients awaiting OLT appears to improve aerobic capacity, and seems feasible and safe. However, larger clinical trials are required to accurately examine the preoperative and postoperative effects of prehabilitation in this specific patient population.
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