Evidence map›Paper›PMID 36157242›Full record

ArticleBioactive materials2023

Injectable nanofiber-reinforced bone cement with controlled biodegradability for minimally-invasive bone regeneration.

Peihao Cai, Shunyi Lu, Jieqin Yu, Lan Xiao, Jiayi Wang, Haifeng Liang, Lei Huang, Guanjie Han, Mengxuan Bian, Shihao Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. [Frontier research on smart delivery biomaterials in the field of oral tissue engineering].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026
    Review
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  8. [Preparation of calcium phosphate nanoflowers and evaluation of their antioxidant and osteogenic induction capabilitiesZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Peihao CaiThe Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Shunyi LuDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jieqin YuDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Lan XiaoCentre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, 4059, Australia.
Jiayi WangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Haifeng LiangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Lei HuangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Guanjie HanDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Mengxuan BianDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Shihao ZhangThe Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Jian ZhangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Changsheng LiuThe Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Libo JiangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yulin LiThe Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Injectable materials show their special merits in regeneration of damaged/degenerated bones in minimally-invasive approach. Injectable calcium phosphate bone cement (CPC) has attracted broad attention for its bioactivity, as compared to non-degradable polymethyl methacrylate cement. However, its brittleness, poor anti-washout property and uncontrollable biodegradability are the main challenges to limit its further clinical application mainly because of its stone-like dense structure and fragile inorganic-salt weakness. Herein, we developed a kind of injectable CPC bone cement with porous structure and improved robustness by incorporating poly(lactide-co-glycolic acid) (PLGA) nanofiber into CPC, with carboxymethyl cellulose (CMC) to offer good injectability as well as anti-wash-out capacity. Furthermore, the introduction of PLGA and CMC also enabled a formation of initial porous structure in the cements, where PLGA nanofiber endowed the cement with a dynamically controllable biodegradability which provided room for cell movement and bone ingrowth. Interestingly, the reinforced biodegradable cement afforded a sustainable provision of Ca

Indexed as

AngiogenesisBiodegradable PLGA nanofiberInjectable calcium phosphate cementMinimally-invasive bone regenerationOsseointegration

Identifiers

PMID36157242
PMCPMC9477970

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.