Evidence map›Paper›PMID 36157103›Full record

ArticleIEEE sensors journal2022

Engineered Electroactive Solutions for Electrochemical Detection of Tuberculosis-Associated Volatile Organic Biomarkers.

Christina N Willis, Shaylee R Larson, Alfred Andama, Devan Jaganath, Manoranjan Misra, Adithya Cattamanchi, Swomitra K Mohanty

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IEEE sensors journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Christina N WillisDepartment of Chemical Engineering, The University of Utah, Salt Lake City, UT 84112, USA.
Shaylee R LarsonDepartment of Chemical Engineering, The University of Utah, Salt Lake City, UT 84112, USA.
Alfred AndamaDepartment of Medicine and the Infectious Disease Research Collaboration, Makerere University College of Health Sciences, Kampala, Uganda.
Devan JaganathDivision of Pediatric Infectious Diseases, the Division of Pulmonary and Critical Care Medicine, and the Center for Tuberculosis, University of California San Francisco, San Francisco, CA 94110, USA.
Manoranjan MisraDepartment of Chemical Engineering and the Department of Materials Science and Engineering, The University of Utah, Salt Lake City, UT 84112, USA.
Adithya CattamanchiDivision of Pulmonary and Critical Care Medicine, the Center for Tuberculosis, and the Center for Vulnerable Populations, University of California San Francisco, San Francisco, CA 94110, USA.
Swomitra K MohantyDepartment of Chemical Engineering and the Department of Materials Science and Engineering, The University of Utah, Salt Lake City, UT 84112, USA.
University of Utah · USUniversity of California, San Francisco · USMakerere University · UGUniversity of Nevada, Reno · US

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
Evaluation of a novel breath sensor for rapid, low-cost diagnosis of tuberculosis in childrenR01HL139717 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KATO-MAEDA, MIDORI, MOHANTY, SWOMITRA K · 2018 to 2021
$2.7M
FIC NIH HHS D43 TW010540NHLBI NIH HHS R01 HL139717
6 · The paper itself

Abstract

Rapid screening of tuberculosis by evaluation of associated volatile organic biomarkers in breath is a promising technology that is significantly faster and more convenient than traditional sputum culture tests. Methyl nicotinate (MN) and methyl p-anisate (MPA) have been isolated as potential biomarkers for mycobacterium tuberculosis and have been found in the breath of patients with active pulmonary tuberculosis. A novel approach to detection of these biomarkers in liquid droplets (e.g. from breath condensate) using inexpensive screen-printed electrodes is presented. Previous modelling studies suggest that these biomarkers complex with certain transition metals of particular valence state. This interaction can be exploited by mixing the biomarker sample into an electroactive solution (EAS) containing the functional metal ion and observing the change electrochemically. The study focuses on low biomarker concentrations, determined to be clinically relevant based on preliminary GC-MS studies of the levels found in patient breath. It was found that both the cyclic voltammogram and square wave voltammogram of copper(II) change significantly when as little as 0.1 mM MN is added to the solution, with analysis times of less than 2 min. Copper(II) exhibits three separate peaks during square wave voltammetry. The location and area of each peak are affected differently as the concentration of MN increases, suggesting a reaction with specific oxidation states of the metal. In this way, a "fingerprint" method can be used to identify biomarkers once their known interaction is established.

Indexed as

Breath BiomarkersElectrochemical SensorsPoint-of-care DiagnosticsTranslational Medicine

Identifiers

PMID36157103
PMCPMC9495895
OpenAlexW3212699909

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.