ArticleMaterials today. Bio2022
Smart nano-in-microparticles to tackle bacterial infections in skin tissue engineering.
Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Zein-based polysaccharide-tannic acid films as multifunctional barriers to prevent post-surgical adhesions.International journal of pharmaceutics: X · 2026Article
- Mechanistic Investigation of Microdroplet Formation in High-Viscosity Shear-Thinning Hydrogel Bioinks.Gels (Basel, Switzerland) · 2026Article
- Recent advances in polymer-based drug delivery systems for atopic dermatitis: enhancing therapeutic efficacy and outcomes.Materials today. Bio · 2025Review
- Smart hybrid nanomaterials for chronic infections: microbiome-responsive and sustainable therapeutic platforms.Journal of nanobiotechnology · 2025Review
- Protein-Based Electrospun Nanofibers Doped with Selenium Nanoparticles for Wound Repair.Pharmaceutics · 2025Article
- Olive mill wastewater: From by-product to smart antioxidant material.International journal of pharmaceutics: X · 2024Article
- Hydroxyapatite-Coated Ti6Al4V ELI Alloy: In Vitro Cell Adhesion.Nanomaterials (Basel, Switzerland) · 2024Article
- High-yield fabrication of monodisperse multilayer nanofibrous microparticles for advanced oral drug delivery applications.Heliyon · 2024Article
- Cerium Oxide and Chondroitin Sulfate Doped Polyurethane Scaffold to Bridge Tendons.ACS applied materials & interfaces · 2023Article
- Nutritional and Functional Properties of Novel Italian Spray-Dried Cricket Powder.Antioxidants (Basel, Switzerland) · 2023Article
- Nanoclay-Doped Electrospun Nanofibers for Tissue Engineering: Investigation on the Structural Modifications in Physiological Environment.International journal of nanomedicine · 2023Article
- Mycelium-based biomaterials as smart devices for skin wound healing.Frontiers in bioengineering and biotechnology · 2023Article
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Authors and funding
14 authors.
Funding
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Abstract
Chronic wounds (resulting from underlying disease, metabolic disorders, infections, trauma, and even tumours) pose significant health problems. In this work, microparticles, based on polysaccharides (maltodextrin or dextran) and amino acids, and doped with antibacterial nanoparticles (CuO or ZnO NPs) are designed. Smart nano-in-microparticles with a hierarchical 3D structure are developed. The ultimate goal aims at an innovative platform to achieve skin repair and to manage skin colonization by avoiding infection that could delay and even impair the healing process. The microparticles are prepared by spray-drying and cross-linked by heating, to obtain insoluble scaffolds able to facilitate cell proliferation in the wound bed. The nano-in-microparticles are characterized using a multidisciplinary approach: chemico-physical properties (SEM, SEM-EDX, size distribution, swelling and degradation properties, structural characterization - FTIR, XRPD, SAXS - mechanical properties, surface zeta potential) and preclinical properties (in vitro biocompatibility and whole-blood clotting properties, release studies and antimicrobial properties, and in vivo safety and efficacy on murine burn/excisional wound model) were assessed. The hierarchical 3D nano-in microparticles demonstrate to promote skin tissue repair in a preclinical study, indicating that this platform deserves particular attention and further investigation will promote the prototypes translation to clinics.
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