Evidence map›Paper›PMID 36156918›Full record

ArticleAddiction neuroscience2022

Ventral pallidum GABA neurons bidirectionally control opioid relapse across rat behavioral models.

Mitchell R Farrell, Qiying Ye, Yiyan Xie, Jeanine Sandra D Esteban, Stephen V Mahler

Open access · goldAbstract read
In one paragraph

Article in Addiction neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Unpacking Ventral Pallidum GABA Neuron Contributions to Opioid Drug Reward in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Article
  4. Ventral pallidal perineuronal nets regulate opioid relapse.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. A Drd1-cre mouse line with nucleus accumbens gene dysregulation exhibits blunted fentanyl seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  7. Article
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  15. Ventral Pallidal GABAergic Neuron Calcium Activity Encodes Cue-Driven Reward Seeking and Persists in the Absence of Reward Delivery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mitchell R FarrellUniversity of California, Irvine Department of Neurobiology and Behavior, 1203 McGaugh Hall Irvine, CA, 92697, USA.
Qiying YeUniversity of California, Irvine Department of Neurobiology and Behavior, 1203 McGaugh Hall Irvine, CA, 92697, USA.
Yiyan XieUniversity of California, Irvine Department of Neurobiology and Behavior, 1203 McGaugh Hall Irvine, CA, 92697, USA.
Jeanine Sandra D EstebanUniversity of California, Irvine Department of Neurobiology and Behavior, 1203 McGaugh Hall Irvine, CA, 92697, USA.
Stephen V MahlerUniversity of California, Irvine Department of Neurobiology and Behavior, 1203 McGaugh Hall Irvine, CA, 92697, USA.
University of California, Irvine · US

Funding

Impact of Cannabinoid Across the Lifespan (ICAL)P50DA044118 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine M Gall · 2018 to 2026
$18.2M
Role of Ventral Pallidum Projection to VTA in Reinstatement of Cocaine SeekingR00DA035251 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MAHLER, STEPHEN VINCENT · 2015 to 2017
$756k
Ventral Pallidum Circuits in Motivation, Risky Decision Making, and Opioid AddictionF99NS120641 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI FARRELL, MITCHELL · 2020 to 2021
$85k
Ventral Pallidum GABA Circuits in Risky Decision MakingF31DA048578 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI FARRELL, MITCHELL · 2019 to 2020
$55k
NIDA NIH HHS F31 DA048578NIDA NIH HHS P50 DA044118NIDA NIH HHS R00 DA035251NINDS NIH HHS F99 NS120641
6 · The paper itself

Abstract

Opioid addiction is a chronic, relapsing disorder. Whether addicted individuals are forced to abstain or they decide themselves to quit using drugs, relapse rates are high-especially upon encountering contexts and stimuli associated with prior opioid use. Rodents similarly show context- and cue-induced reinstatement of drug seeking following abstinence, and intriguingly, the neural circuits underlying these relapse-like behaviors differ when abstinence is involuntarily imposed, responding is extinguished, or animals decide themselves to cease taking drug. Here, we employ two complementary rat behavioral models of relapse-like behavior for the highly reinforcing opioid drug remifentanil, and asked whether GABAergic neurons in the ventral pallidum (VP

Indexed as

AbstinenceChemogeneticsDREADDsExtinctionPunishmentReinstatementRemifentanil

Identifiers

PMID36156918
PMCPMC9494709
OpenAlexW4283725363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.