ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2022
Associations between pre- and postnatal antibiotic exposures and early allergic outcomes: A population-based birth cohort study.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Prenatal maternal antibiotic use increases the risk of childhood eczema: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and Meta-Analysis.JAMA pediatrics · 2026Pooled it
- Prevalence of systemic antibacterial use during pregnancy worldwide: A systematic review.PloS one · 2024Pooled it
- Prenatal and Early-Life Exposure to Microbiome-Modulating Medications and the Risk of Childhood Food Allergy: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Early-life exposure to antibiotics increases the risk of myopia: A retrospective cohort study.BioMedicine · 2026Article
- Association Between Prenatal Antibiotic Exposure and Infant Wheeze Outcomes.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Maternal dietary inflammatory index during pregnancy and the risk of offspring allergic disease.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Association of Prenatal and Intrapartum Antibiotic Use with Risk of Childhood Atopic Dermatitis: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2025Review
- When infection hurts: golden rules for managing pediatric skin and soft tissue infections.Italian journal of pediatrics · 2025Review
- Association between antibiotic exposure and childhood atopic dermatitis: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Role of the microbiota-gut-lung axis in the pathogenesis of pulmonary disease in children and novel therapeutic strategies.Frontiers in immunology · 2025Review
- Maternal influences on offspring food allergy.Immunological reviews · 2024Review
- Factors influencing C-reactive protein status on admission in neonates after birth.BMC pediatrics · 2024Article
- [Recent research on the relationship between pulmonary microbiome and asthma endotypes in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
- Fruit Pouch Consumption Does Not Associate with Early Manifestations of Allergic Disease.Nutrients · 2023Article
- Contributions of the early-life microbiome to childhood atopy and asthma development.Seminars in immunology · 2023Review
- Are Babies Born Preterm High-Risk Asthma Candidates?Journal of clinical medicine · 2023Review
- Primary Prevention of Allergy - Is It Feasible?Allergy, asthma & immunology research · 2023Review
- Appropriate Use of Antibiotic and Principles of Antimicrobial Stewardship in Children.Children (Basel, Switzerland) · 2023Article
- Maternal exposure to antibiotics and risk of atopic dermatitis in childhood: a systematic review and meta-analysis.Frontiers in pediatrics · 2023Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly life antibiotic treatment is one likely exposure influencing allergy risk. The objective was to investigate associations between pre- and postnatal antibiotic exposures and the development of allergic manifestations until age 18 months.
methodsWe included 1387 mother-child dyads from the prospective, population-based NorthPop birth cohort study. Data on antibiotic exposures in pregnancy and childhood were collected by web-based questionnaires. Until the child turned 18 months old, parents (n = 1219) reported symptoms of wheeze, eczema, and physician-diagnosed asthma; parents (n = 1025) reported physician-diagnosed food allergy. At age 18 months, serum immunoglobulin E levels to inhalant (Phadiatop) and food (Food mix fx5) allergens were determined. Associations were estimated using bivariable and multivariable logistic regressions.
resultsPrenatal antibiotic exposure was positively associated with food sensitization in the crude (OR 1.82, 95% CI 1.01-3.26) but not in the adjusted analyses (aOR 1.58, 0.82-3.05). A borderline significant association was found between prenatal exposure and wheeze (aOR 1.56, 0.95-2.57). Postnatal antibiotics were positively associated with wheeze (aOR 2.14, 1.47-3.11), asthma (aOR 2.35, 1.32-4.19), and eczema (aOR 1.49, 1.07-2.06). Postnatal antibiotics were negatively associated with food sensitization (aOR 0.46, 95% CI 0.25-0.83) but not with food allergy nor sensitization to inhalants.
conclusionPre- and postnatal antibiotic exposure demonstrated positive associations with allergic manifestations and the former also with food sensitization. In contrast, there was a negative association between postnatal antibiotics and food sensitization. Food sensitization is often transient but may precede respiratory allergies. Future studies should investigate the relationship between antibiotic exposure and food sensitization later in childhood.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.