Evidence map›Paper›PMID 36156760›Full record

ArticlePurinergic signalling2023

The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors.

Pedro Valada, Sonja Hinz, Christin Vielmuth, Cátia R Lopes, Rodrigo A Cunha, Christa E Müller, João Pedro Lopes

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Purinergic signalling, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Pedro ValadaCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal.
Sonja HinzPharmaceutical & Medicinal Chemistry, University of Bonn, 53121, Bonn, Germany.
Christin VielmuthPharmaceutical & Medicinal Chemistry, University of Bonn, 53121, Bonn, Germany.
Cátia R LopesCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal.
Rodrigo A CunhaCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal. cunharod@gmail.com.ORCID 0000-0003-2550-6422
Christa E MüllerPharmaceutical & Medicinal Chemistry, University of Bonn, 53121, Bonn, Germany.
João Pedro LopesCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal.
University of Coimbra · PTUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inosine has robust neuroprotective effects, but it is unclear if inosine acts as direct ligand of adenosine receptors or if it triggers metabolic effects indirectly modifying the activity of adenosine receptors. We now combined radioligand binding studies with electrophysiological recordings in hippocampal slices to test how inosine controls synaptic transmission and plasticity. Inosine was without effect at 30 μM and decreased field excitatory post-synaptic potentials by 14% and 33% at 100 and 300 μM, respectively. These effects were prevented by the adenosine A

Indexed as

AdenosineNucleosidesAnimalsHippocampusHumansInosinePurinergic P1 Receptor AntagonistsRatsReceptor, Adenosine A1Synaptic TransmissionAdenosineInosineNucleosidesPurinergic P1 Receptor AntagonistsReceptor, Adenosine A1A1 receptorA2A receptorAdenosineHippocampusInosineSynaptic plasticitySynaptic transmission

Identifiers

PMID36156760
PMCPMC10247617
OpenAlexW4297201466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.