Evidence map›Paper›PMID 36156420›Full record

ArticleMedical image analysis2022

TransMorph: Transformer for unsupervised medical image registration.

Junyu Chen, Eric C Frey, Yufan He, William P Segars, Ye Li, Yong Du

Open access · greenAbstract read
In one paragraph

Article in Medical image analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 2 pooled it
60.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 2 syntheses or guidelines pooled it, 653 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. AI in Proton Therapy Treatment Planning: A Narrative Review.International journal of particle therapy · 2026
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  20. GuidedMorph: Two-Stage Deformable Registration for Breast MRI.IEEE journal of biomedical and health informatics · 2026
    Article

72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Junyu ChenRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutes, Baltimore, MD, USA; Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA. Electronic address: jchen245@jhmi.edu.
Eric C FreyRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutes, Baltimore, MD, USA; Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA. Electronic address: efrey@jhmi.edu.
Yufan HeNVIDIA Corporation, Bethesda, MD, USA. Electronic address: yufanh@nvidia.com.
William P SegarsCarl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, NC, USA. Electronic address: paul.segars@duke.edu.
Ye LiCenter for Advanced Medical Computing and Analysis, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: gary.li@mgh.harvard.edu.
Yong DuRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutes, Baltimore, MD, USA. Electronic address: duyong@jhmi.edu.
Johns Hopkins University · USDuke University · USHarvard University · USNvidia (United Kingdom) · GB

Funding

Multi-Modality Quantitiative Imaging for Evaluation of Response to Cancer TherapyU01CA140204 · NCI · JOHNS HOPKINS UNIVERSITY · PI DU, YONG, SOLNES, LILJA · 2011 to 2022
$6.1M
High Energy and Spatial Resolution Multi-Isotope SPECT Imaging of Targeted Alpha-Emitters and their DaughtersU01EB031798 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI DU, YONG, FREY, ERIC C. · 2021 to 2025
$3.8M
Hyperspectral Single Photon Imaging of Targeted Alpha-EmittersR01EB031023 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI DU, YONG, GHALY, MICHAEL · 2021 to 2024
$2.7M
Precision Cardiac CT: Development of a Computational Platform for Optimizing ImagingR01HL131753 · NHLBI · DUKE UNIVERSITY · PI SAMEI, EHSAN, SEGARS, WILLIAM P · 2017 to 2020
$2.7M
NCI NIH HHS U01 CA140204NHLBI NIH HHS R01 HL131753NIBIB NIH HHS R01 EB031023NIBIB NIH HHS U01 EB031798
6 · The paper itself

Abstract

In the last decade, convolutional neural networks (ConvNets) have been a major focus of research in medical image analysis. However, the performances of ConvNets may be limited by a lack of explicit consideration of the long-range spatial relationships in an image. Recently, Vision Transformer architectures have been proposed to address the shortcomings of ConvNets and have produced state-of-the-art performances in many medical imaging applications. Transformers may be a strong candidate for image registration because their substantially larger receptive field enables a more precise comprehension of the spatial correspondence between moving and fixed images. Here, we present TransMorph, a hybrid Transformer-ConvNet model for volumetric medical image registration. This paper also presents diffeomorphic and Bayesian variants of TransMorph: the diffeomorphic variants ensure the topology-preserving deformations, and the Bayesian variant produces a well-calibrated registration uncertainty estimate. We extensively validated the proposed models using 3D medical images from three applications: inter-patient and atlas-to-patient brain MRI registration and phantom-to-CT registration. The proposed models are evaluated in comparison to a variety of existing registration methods and Transformer architectures. Qualitative and quantitative results demonstrate that the proposed Transformer-based model leads to a substantial performance improvement over the baseline methods, confirming the effectiveness of Transformers for medical image registration.

Indexed as

Imaging, Three-DimensionalNeural Networks, ComputerBayes TheoremHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingPhantoms, ImagingComputerized phantomDeep learningImage registrationVision transformer

Identifiers

PMID36156420
PMCPMC9999483
OpenAlexW4226497331

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.