ArticleBiomaterials2022
Canonical Wnt signaling enhances pro-inflammatory response to titanium by macrophages.
Article in Biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Wnt Signaling Across Adult Skin Mini-Organs: Interfollicular Epidermis, Hair Follicle, and Nail-Implications for Disease and Regeneration.International journal of molecular sciences · 2026Review
- Prolonged Wnt3a exposure tolerizes macrophages to inflammatory stimuli.Frontiers in immunology · 2026Article
- Distinctive fish collagen drives vascular regeneration by polarizing macrophages to M2 phenotype via TNF-α/NF-κB pathway.Materials today. Bio · 2025Article
- Healing of tendon-related diseases: insights from macrophage regulation.Military Medical Research · 2025Review
- Obesity prolongs the pro-inflammatory response and attenuates bone healing on titanium implants.Acta biomaterialia · 2025Article
- Adoptive transfer of immunomodulatory macrophages reduces the pro-inflammatory microenvironment and increases bone formation on titanium implants.Acta biomaterialia · 2024Article
- Pig Milk Exosome Packaging ssc-miR-22-3p Alleviates Pig Intestinal Epithelial Cell Injury and Inflammatory Response by TargetingInternational journal of molecular sciences · 2024Article
- Silk films with distinct surface topography modulate plasma membrane curvature to polarize macrophages.Materials today. Bio · 2024Article
- CD4Acta biomaterialia · 2024Article
- Signaling pathways of dental implants' osseointegration: a narrative review on two of the most relevant; NF-κB and Wnt pathways.BDJ open · 2024Review
- Article
- Contribution of αβ T cells to macrophage polarization and MSC recruitment and proliferation on titanium implants.Acta biomaterialia · 2023Article
- Reduction of neutrophil extracellular traps accelerates inflammatory resolution and increases bone formation on titanium implants.Acta biomaterialia · 2023Article
- Immune cell response to orthopedic and craniofacial biomaterials depends on biomaterial composition.Acta biomaterialia · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Biomaterial characteristics like surface roughness and wettability can determine the phenotype of macrophages following implantation. We have demonstrated that inhibiting Wnt ligand secretion abolishes macrophage polarization in vitro and in vivo; however, the role of canonical Wnt signaling in macrophage activation in response to physical and chemical biomaterial cues is unknown. The aim of this study was to understand whether canonical Wnt signaling affects the response of macrophages to titanium (Ti) surface roughness or wettability in vitro and in vivo. Activating canonical Wnt signaling increased expression of toll-like receptors and interleukin receptors and secreted pro-inflammatory cytokines and reduced anti-inflammatory cytokines on Ti, regardless of surface properties. Inhibiting canonical Wnt signaling reduced pro-inflammatory cytokines on all Ti surfaces and increased anti-inflammatory cytokines on rough or rough-hydrophilic Ti. In vivo, activating canonical Wnt signaling increased total macrophages, pro-inflammatory macrophages, and T cells and decreased anti-inflammatory macrophages on both smooth and rough-hydrophilic implants. Functionally, canonical Wnt activation increases pro-inflammatory macrophage response to cell and cell-extracellular matrix lysates. These results demonstrate that activating canonical Wnt signaling primes macrophages to a pro-inflammatory phenotype that affects their response to Ti implants in vitro and in vivo.
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Registered trials
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