ArticleEMBO reports2022
MCU controls melanoma progression through a redox-controlled phenotype switch.
Open access · hybridAbstract read
In one paragraph
Article in EMBO reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity.Molecular oncology · 2026Article
- Inhibition of Calcium-Dependent Lipid Droplets Relocation of ACSL4-PKCβ-ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Neuro-Melanoma Singularity: Convergent Evolution of Neural and Melanocytic Networks in Brain Metastatic Adaptation.Biomolecules · 2025Review
- Mitochondrial CaJournal of cellular physiology · 2025Review
- Inter-Organellar CaCells · 2025Review
- Mitochondrial metabolism and cancer therapeutic innovation.Signal transduction and targeted therapy · 2025Review
- Metabolic reprogramming in melanoma therapy.Cell death discovery · 2025Review
- Mitochondrial CaCell reports · 2025Article
- Lactate-associated gene MCU promotes the proliferation, migration, and invasion of pancreatic ductal adenocarcinoma.BMC cancer · 2025Article
- Crosstalk between calcium and reactive oxygen species signaling in cancer revisited.Cell calcium · 2025Review
- Mitochondrial calcium uniporter as biomarker and therapeutic target for breast cancer: Prognostication, immune microenvironment, epigenetic regulation and precision medicine.Journal of advanced research · 2025Article
- A hybrid machine learning framework for functional annotation of mitochondrial glutathione transport and metabolism proteins in cancers.BMC bioinformatics · 2025Article
- A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism.Nature communications · 2024Article
- Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness.The EMBO journal · 2023Article
- The Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Role in Human Diseases.Biomolecules · 2023Review
- The mitochondrial CabioRxiv : the preprint server for biology · 2023Article
- The mitochondrial CaFrontiers in cell and developmental biology · 2023Article
- Article
- The sun, cholesterol and Orai1 conspire in melanoma.The EMBO journal · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 5 institutions in 2 countries.
Ioana Stejerean-Todoran *Molecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany.ORCID 0000-0002-4225-5912
Katharina Zimmermann *Biophysics, CIPMM, Saarland University, Homburg, Germany.
Christine S Gibhardt *Molecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany.ORCID 0000-0001-5104-970X
Adina VulturMolecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany.ORCID 0000-0003-0068-9496
Christian IckesMolecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany.
Batool ShannanThe Wistar Institute, Melanoma Research Center, Philadelphia, PA, USA.
Zuriñe Bonilla Del RioMolecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany.ORCID 0000-0001-8997-8459
Anna WöllingDepartment of Dermatology, Venereology and Allergology, University Medical Center, Georg-August-University, Göttingen, Germany.
Sabrina CappelloMolecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany.
Hsu-Min SungMolecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany.
Magdalena ShumanskaMolecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany.ORCID 0000-0002-7999-6781
Xin ZhangMolecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany.ORCID 0000-0001-8057-9259
Maithily NanadikarDepartment of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University, Göttingen, Germany.
Muhammad U LatifDepartment of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Gottingen, Germany.ORCID 0000-0002-6198-3069
Anna WittekDepartment of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Felix LangeDepartment of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Andrea WatersThe Wistar Institute, Melanoma Research Center, Philadelphia, PA, USA.
Patricia BraffordThe Wistar Institute, Melanoma Research Center, Philadelphia, PA, USA.
Jörg WiltingDepartment of Anatomy and Cell Biology, University Medical Center, Georg-August-University, Göttingen, Germany.
Henning UrlaubBioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0000-0003-1837-5233
Dörthe M KatschinskiDepartment of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University, Göttingen, Germany.ORCID 0000-0003-4630-9081
Peter RehlingDepartment of Cellular Biochemistry, University Medical Center Göttingen, GZMB, Göttingen, Germany.ORCID 0000-0001-5661-5272
Christof LenzBioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0000-0002-0946-8166
Stefan JakobsDepartment of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0000-0002-8028-3121
Volker EllenriederDepartment of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Gottingen, Germany.
Alexander RoeschDepartment of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK).
Michael P SchönDepartment of Dermatology, Venereology and Allergology, University Medical Center, Georg-August-University, Göttingen, Germany.ORCID 0000-0002-0698-4130
Meenhard HerlynThe Wistar Institute, Melanoma Research Center, Philadelphia, PA, USA.
Hedwig StaniszDepartment of Dermatology, Venereology and Allergology, University Medical Center, Georg-August-University, Göttingen, Germany.
Ivan BogeskiMolecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany.ORCID 0000-0001-9879-7174
University of Göttingen · DEUniversitätsmedizin Göttingen · DEThe Wistar Institute · USGerman Cancer Research Center · DESaarland University · DE
Funding
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Aaron Robert Goldman · 1985 to 2026
$75.9MNCI NIH HHS P30 CA010815
Abstract
Melanoma is the deadliest of skin cancers and has a high tendency to metastasize to distant organs. Calcium and metabolic signals contribute to melanoma invasiveness; however, the underlying molecular details are elusive. The MCU complex is a major route for calcium into the mitochondrial matrix but whether MCU affects melanoma pathobiology was not understood. Here, we show that MCU
Indexed as
CalciumMelanomaCell Line, TumorHumansOxidation-ReductionPhenotypeProteomicsCalciumcalciumMCUmelanomamitochondriaROS
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.