Evidence map›Paper›PMID 36156108›Full record

Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2023

Manipulation of Menthol and Nicotine Content in Cigarettes: Effects on Smoking Behavior and Toxicant Exposure in Women Menthol Smokers.

Cheryl Oncken, Mark D Litt, Sheila Thurlow, Erin L Mead-Morse, Lanqing Wang, Dorothy K Hatsukami

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. The Impact of Menthol Cigarette Bans: A Systematic Review and Meta-Analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Cheryl OnckenUniversity of Connecticut School of Medicine, Farmington, CT 06030, USA.
Mark D LittUniversity of Connecticut School of Medicine, Farmington, CT 06030, USA.ORCID 0000-0002-8319-6090
Sheila ThurlowUniversity of Connecticut School of Medicine, Farmington, CT 06030, USA.
Erin L Mead-MorseUniversity of Connecticut School of Medicine, Farmington, CT 06030, USA.ORCID 0000-0002-9720-2658
Lanqing WangCenters for Disease Control and Prevention, Atlanta, GA 30341, USA.ORCID 0000-0001-6620-7096
Dorothy K HatsukamiUniversity of Minnesota Medical School, Minneapolis, MN 55455, USA.ORCID 0000-0002-1108-2609
University of Connecticut · USCenters for Disease Control and Prevention · USUniversity of Minnesota Medical Center · US

Funding

Manipulating Tobacco Constituents in Female Menthol SmokersR01DA036486 · NIDA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HESSELBROCK, VICTOR M · 2013 to 2017
$3.4M
Impact of Cigar Flavor on Tobacco Use Behaviors and Addiction in Dual UsersK01DA048494 · NIDA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MEAD-MORSE, ERIN LUCIA · 2019 to 2024
$1.1M
FDA HHSNIDA NIH HHS K01 DA048494NIDA NIH HHS K01DA048494NIDA NIH HHS R01 DA036486
6 · The paper itself

Abstract

backgroundThe purpose of this study was to determine the effects of smoking and other outcomes of assigning cigarettes with reduced nicotine and/or no menthol to female menthol smokers. AIMS AND

methodsNontreatment-seeking female menthol smokers (N = 263) participated in a randomized controlled trial in which levels of menthol and nicotine in cigarettes were manipulated using experimental cigarettes. After a baseline period, participants were assigned to the following conditions for 6 weeks: (1) their own brand of cigarette (conventional nicotine with menthol), (2) a conventional nicotine cigarette with no menthol, (3) a cigarette with reduced nicotine (RNC) with menthol, or (4) a RNC cigarette and no menthol. Participants then returned to using their own brand and were followed for another 6 weeks. Outcomes included cigarettes smoked, biomarkers of exposure, and dependence measures.

resultsResults indicated that, after an initial increase, rates of smoking of all three experimental cigarettes were at or below baseline rates of smoking of one's own brand. Levels of biomarkers also decreased during the experimental phase but rebounded somewhat after participants resumed smoking their own brand. There was evidence that the overall amount of smoking decreased similarly among women who switched to non-menthol and/or RNC cigarettes.

conclusionsThese results suggest that no detrimental effect will occur in nicotine or toxicant exposure levels with a ban on characterizing menthol and/or a product standard on nicotine content in cigarettes. IMPLICATIONS: The implication of this work is that there would be no risk to women menthol smokers associated with regulations restricting nicotine and eliminating menthol in cigarettes.

Indexed as

NicotineTobacco ProductsBiomarkersFemaleHumansMentholSmokersSmokingBiomarkersMentholNicotine

Identifiers

PMID36156108
PMCPMC10032200
OpenAlexW4297264804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.