Evidence map›Paper›PMID 36155953›Full record

ArticleBiosensors & bioelectronics2022

Nanozyme-strip for rapid and ultrasensitive nucleic acid detection of SARS-CoV-2.

Xiangqin Meng, Sijia Zou, Dandan Li, Jiuyang He, Ling Fang, Haojue Wang, Xiyun Yan, Demin Duan, Lizeng Gao

Abstract read
In one paragraph

Article in Biosensors & bioelectronics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Peroxidase-Mimicking Nanozymes for Rapid Detection of Infectious Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Review
  4. FePlants (Basel, Switzerland) · 2026
    Article
  5. Article
  6. Biomedical Applications of Nanozymes: An Enzymology Perspective.Angewandte Chemie (International ed. in English) · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiangqin MengCAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academic of Science, Beijing, 100101, China.
Sijia ZouCAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academic of Science, Beijing, 100101, China; School of Basic Medical Science, Southwest Medical University, Luzhou, 646000, China.
Dandan LiSchool of Medicine, Institute of Translational Medicine, Yangzhou University, Yangzhou, 225001, China.
Jiuyang HeCAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academic of Science, Beijing, 100101, China.
Ling FangXishan People's Hospital of Wuxi City, Wuxi, Jiangsu, 214105, China.
Haojue WangXishan People's Hospital of Wuxi City, Wuxi, Jiangsu, 214105, China.
Xiyun YanCAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academic of Science, Beijing, 100101, China; Nanozyme Medical Center, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450052, China; Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. Electronic address: yanxy@ibp.ac.cn.
Demin DuanCAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academic of Science, Beijing, 100101, China. Electronic address: dmduan@ibp.ac.cn.
Lizeng GaoCAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academic of Science, Beijing, 100101, China; Nanozyme Medical Center, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450052, China. Electronic address: gaolizeng@ibp.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has created a huge demand for sensitive and rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The current gold standard for SARS-CoV-2 detection is reverse transcription-polymerase chain reaction (RT-PCR)-based nucleic acid amplification. However, RT-PCR is time consuming and requires specialists and large instruments that are unattainable for point-of-care testing (POCT). To develop POCT for SARS-CoV-2, we combined recombinase polymerase amplification (RPA) and FeS

Indexed as

Biosensing TechniquesCOVID-19Nucleic AcidsHumansNucleic Acid Amplification TechniquesPeroxidasesRecombinasesReproducibility of ResultsRNA, ViralSARS-CoV-2Sensitivity and SpecificityNucleic AcidsPeroxidasesRecombinasesRNA, ViralHPV-16Nanozyme stripsNucleic acid detectionPoint-of-care testingRecombinase polymerase amplificationSARS-CoV-2

Identifiers

PMID36155953
PMCPMC9484135

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.