Evidence map›Paper›PMID 36155778›Full record

ArticleAlcohol (Fayetteville, N.Y.)2023

Sex-specific effects of ethanol consumption in older Fischer 344 rats on microglial dynamics and Aβ

Paige Marsland, Andrew S Vore, Evan DaPrano, Joanna M Paluch, Ashley A Blackwell, Elena I Varlinskaya, Terrence Deak

Open access · greenAbstract read
In one paragraph

Article in Alcohol (Fayetteville, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Adolescent Alcohol and the Spectrum of Cognitive Dysfunction in Aging.Advances in experimental medicine and biology · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Alcohol Use Disorder and Dementia: A Review.Alcohol research : current reviews · 2024
    Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Paige MarslandBehavioral Neuroscience Program, Department of Psychology, Binghamton University, Binghamton, NY 13902-6000, United States.
Andrew S VoreBehavioral Neuroscience Program, Department of Psychology, Binghamton University, Binghamton, NY 13902-6000, United States.
Evan DaPranoBehavioral Neuroscience Program, Department of Psychology, Binghamton University, Binghamton, NY 13902-6000, United States.
Joanna M PaluchBehavioral Neuroscience Program, Department of Psychology, Binghamton University, Binghamton, NY 13902-6000, United States.
Ashley A BlackwellBehavioral Neuroscience Program, Department of Psychology, Binghamton University, Binghamton, NY 13902-6000, United States.
Elena I VarlinskayaBehavioral Neuroscience Program, Department of Psychology, Binghamton University, Binghamton, NY 13902-6000, United States.
Terrence DeakBehavioral Neuroscience Program, Department of Psychology, Binghamton University, Binghamton, NY 13902-6000, United States. Electronic address: tdeak@binghamton.edu.
Binghamton University · US

Funding

Social Anxiety, Stress and Ethanol Sensitivity in Adolescence and AdulthoodP50AA017823 · NIAAA · UPSTATE MEDICAL UNIVERSITY · PI J. DAVID JENTSCH · 2009 to 2026
$30.5M
Development and Neuroadaptations in Alcohol and Addictions (DNA2)T32AA025606 · NIAAA · STATE UNIVERSITY OF NY,BINGHAMTON · PI J. DAVID JENTSCH · 2017 to 2026
$2.7M
Long Lasting Effects of Adolescent Alcohol on Blood-Brain-Barrier FunctionF31AA027959 · NIAAA · STATE UNIVERSITY OF NY,BINGHAMTON · PI VORE, ANDREW S · 2019 to 2020
$50k
NIAAA NIH HHS F31 AA027959NIAAA NIH HHS P50 AA017823NIAAA NIH HHS T32 AA025606
6 · The paper itself

Abstract

Chronic alcohol consumption, Alzheimer's disease (AD), and vascular dementia are all associated with cognitive decline later in life, raising questions about whether their underlying neuropathology may share some common features. Indeed, recent evidence suggests that ethanol exposure during adolescence or intermittent drinking in young adulthood increased neuropathological markers of AD, including both tau phosphorylation and beta-amyloid (Aβ) accumulation. The goal of the present study was to determine whether alcohol consumption later in life, a time when microglia and other neuroimmune processes tend to become overactive, would influence microglial clearance of Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesCognitive DysfunctionEthanolMicrogliaAge FactorsAlcohol DrinkingAnimalsChronic DiseaseFemaleMaleMice, TransgenicPeptide FragmentsPhagocytosisRatsSex FactorsAmyloid beta-Peptidesamyloid beta-protein (1-42)EthanolPeptide FragmentsAgingAmyloid betaChronic ethanolMicrogliaSex differences

Identifiers

PMID36155778
PMCPMC10251491
OpenAlexW4296640336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.