ArticleMicrobiome2022
A global phylogenomic and metabolic reconstruction of the large intestine bacterial community of domesticated cattle.
Article in Microbiome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Beyond the Rumen: Current Evidence and Knowledge Gaps in Microbial Diversity and Function Across the Bovine Gastrointestinal Tract.Current microbiology · 2026Review
- Gut-protective metabolic phenotype for diarrhoeal remission caused by an environmental probiotic thermophile.Microbiome · 2026Article
- Impact of ceftiofur administration andmSystems · 2026Article
- Peripartum hypophosphatemia is associated with a hindgut-centered microbiota-metabolite-host axis in transition dairy cows.NPJ biofilms and microbiomes · 2026Article
- Integrative Multi-Omics Analysis of the Rumen inMicroorganisms · 2025Article
- Organic Iron Supplementation in Cows and Its Impacts on Animal Health and Production.Animals : an open access journal from MDPI · 2025Article
- Genomic evidence for flies as carriers of zoonotic pathogens on dairy farms.NPJ biofilms and microbiomes · 2025Article
- A metagenomic catalogue of the ruminant gut archaeome.Nature communications · 2024Article
- Integrated Microbiome and Serum Metabolome Analysis Reveals Molecular Regulatory Mechanisms of the Average Daily Weight Gain of Yorkshire Pigs.Animals : an open access journal from MDPI · 2024Article
- Impact of Dietary Regime and Seasonality on Hindgut's Mycobiota Diversity in Dairy Cows.Microorganisms · 2023Article
- Nutrient availability of roughages in isocaloric and isonitrogenous diets alters the bacterial networks in the whole gastrointestinal tract of Hu sheep.BMC microbiology · 2023Article
- Host innate immune responses and microbiome profile of neonatal calves challenged withFrontiers in cellular and infection microbiology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe large intestine is a colonization site of beneficial microbes complementing the nutrition of cattle but also of zoonotic and animal pathogens. Here, we present the first global gene catalog of cattle fecal microbiomes, a proxy of the large intestine microbiomes, from 436 metagenomes from six countries.
resultsPhylogenomics suggested that the reconstructed genomes and their close relatives form distinct branches and produced clustering patterns that were reminiscent of the metagenomics sample origin. Bacterial taxa had distinct metabolic profiles, and complete metabolic pathways were mainly linked to carbohydrates and amino acids metabolism. Dietary changes affected the community composition, diversity, and potential virulence. However, predicted enzymes, which were part of complete metabolic pathways, remained present, albeit encoded by different microbes.
conclusionsOur findings provide a global insight into the phylogenetic relationships and the metabolic potential of a rich yet understudied bacterial community and suggest that it provides valuable services to the host. However, we tentatively infer that members of that community are not irreplaceable, because similar to previous findings, symbionts of complex bacterial communities of mammals are expendable if there are substitutes that can perform the same task. Video Abstract.
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