Evidence map›Paper›PMID 36155327›Full record

ArticleAtherosclerosis2022

Growth hormone concentration and risk of all-cause and cardiovascular mortality: The REasons for Geographic And Racial Disparities in Stroke (REGARDS) study.

Nicholas Wettersten, Rohit Mital, Mary Cushman, George Howard, Suzanne E Judd, Virginia J Howard, Monika M Safford, Oliver Hartmann, Andreas Bergmann, Joachim Struck and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Nicholas WetterstenDivision of Cardiovascular Medicine, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA; Division of Cardiovascular Medicine, University of California, San Diego, La Jolla, CA, USA. Electronic address: nwettersten@health.ucsd.edu.
Rohit MitalDepartment of Cardiovascular Diseases, Mayo Clinic, Scottsdale, AZ, USA.
Mary CushmanDepartments of Medicine and Pathology & Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.
George HowardDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Suzanne E JuddDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Virginia J HowardDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Monika M SaffordDivision of General Internal Medicine, Weill Cornell Medicine, New York, NY, USA.
Oliver HartmannSphingoTec GmbH, Neuendorfstr. 15 A, 16761 Hennigsdorf, Germany.
Andreas BergmannSphingoTec GmbH, Neuendorfstr. 15 A, 16761 Hennigsdorf, Germany.
Joachim StruckSphingoTec GmbH, Neuendorfstr. 15 A, 16761 Hennigsdorf, Germany.
Alan MaiselDivision of Cardiovascular Medicine, University of California, San Diego, La Jolla, CA, USA.
University of Alabama at Birmingham · USCornell University · USMayo Clinic in Arizona · USUC San Diego Health System · USUniversity of California San Diego · USUniversity of Vermont · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Discriminating Causes of Creatinine Change in Acute Heart FailureIK2CX002105 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI Nicholas Wettersten · 2021 to 2026
–
CSRD VA IK2 CX002105NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

BACKGROUND AND

aimsIdentifying individuals at elevated risk for mortality, especially from cardiovascular disease, may help guide testing and treatment. Risk factors for mortality differ by sex and race. We investigated the association of growth hormone (GH) with all-cause and cardiovascular mortality in a racially diverse cohort in the United States.

methodsAmong an age, sex and race stratified subgroup of 1046 Black and White participants from the REasons for Geographic And Racial Disparities in Stroke (REGARDS) study, 881 had GH available; values were log

resultsThe mean age was 67.4 years, 51.1% were women, and 50.2% were Black participants. The median GH was 280 (interquartile range 79-838) ng/L. There were 237 deaths and 74 cardiovascular deaths over a mean of 8.0 years. In multivariable Cox analysis, GH was associated with higher risk of all-cause mortality per doubling (hazard ratio [HR] 1.17, 95% confidence interval [CI] 1.09-1.25) and cardiovascular mortality (HR 1.21, 95% CI 1.06-1.37). The association did not differ by sex or race (interaction p > 0.05). The addition of GH to a model of clinical variables significantly improved the C-index compared to clinical model alone for all-cause and cardiovascular death.

conclusionsHigher fasting GH was associated with higher risk of all-cause and cardiovascular mortality and improved risk prediction, regardless of sex or race.

Indexed as

Cardiovascular DiseasesStrokeAgedCohort StudiesFemaleGrowth HormoneHumansMaleRisk FactorsUnited StatesGrowth HormoneBiomarkerCardiovascular diseaseGrowth hormonePrediction

Identifiers

PMID36155327
PMCPMC11427131
OpenAlexW4295809090

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.