ArticleInternational journal of radiation oncology, biology, physics2023
TVL1-IMPT: Optimization of Peak-to-Valley Dose Ratio Via Joint Total-Variation and L1 Dose Regularization for Spatially Fractionated Pencil-Beam-Scanning Proton Therapy.
Article in International journal of radiation oncology, biology, physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 29 citations in OpenAlex.
- Exploratory personalized radiobiological modeling of bystander and immune effects to inform SFRT-SBRT scheduling.Medical physics · 2026Article
- Photon minibeam-based LATTICE radiotherapy for small and medium-sized tumors: A dosimetric planning study.Medical physics · 2026Article
- An integrated toolkit for structure generation, optimization, and evaluation in spatially fractionated radiation therapy.Journal of applied clinical medical physics · 2026Article
- Experimental characterization of proton minibeam therapy delivery under FLASH dose-rate conditions.Scientific reports · 2026Article
- Dose optimization with fully flexible vertex positioning for LATTICE radiotherapy.Medical physics · 2026Article
- Advancing Proton Therapy: Integration of Minibeam Spatial Fractionation and FLASH Dose Rates.Research square · 2025Article
- Article
- Development and experimental validation of an in-house treatment planning system with greedy energy layer optimization for fast IMPT.Medical physics · 2025Article
- A fully flexible joint lattice position and dose optimization method for LATTICE therapy.ArXiv · 2025Article
- Direct minimization of normal-tissue toxicity via an NTCP-based IMPT planning method.Medical physics · 2025Article
- 2V-CBCT: Two-Orthogonal-Projection Based CBCT Reconstruction and Dose Calculation for Radiation Therapy Using Real Projection Data.IEEE transactions on medical imaging · 2025Article
- Optimization method for determining vertices in lattice radiotherapy.Frontiers in oncology · 2025Article
- Proton minibeam radiotherapy: a review.Frontiers in oncology · 2025Review
- Proton ARC based LATTICE radiation therapy: feasibility study, energy layer optimization and LET optimization.Physics in medicine and biology · 2024Article
- TEAM: Triangular-mEsh Adaptive and Multiscale proton spot generation method.Medical physics · 2024Article
- Simultaneous dose and dose rate optimization via dose modifying factor modeling for FLASH effective dose.Medical physics · 2024Article
- Biological optimization for hybrid proton-photon radiotherapy.Physics in medicine and biology · 2024Article
- Hypoxia-informed RBE-weighted beam orientation optimization for intensity modulated proton therapy.Medical physics · 2024Article
- Optimizing linear energy transfer distribution in intensity-modulated proton therapy using the alternating direction method of multipliers.Frontiers in oncology · 2024Article
- Lattice position optimization for LATTICE therapy.Medical physics · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
purposeProton minibeam radiation therapy (pMBRT) is a novel proton modality of spatially fractionated RT. pMBRT can reduce the radiation damage to normal tissues via biological dose sparing of high peak-to-valley dose ratio (PVDR). This work will develop a new spatially fractionated IMPT treatment planning method for pMBRT that jointly optimizes the plan quality and maximizes the PVDR.
methodsThe new optimization method simultaneously maximizes the normal-tissue PVDR and optimizes the dose distribution at tumor targets and organs at risk. The PVDR maximization is through the joint total variation (TV) and L1 regularization with respect to the normal-tissue dose. That is, the beam-eye view projects dose slices of several depths for each beam angle; the TV of dose is maximized, corresponding to the PVDR maximization; and the L1 of dose is minimized, corresponding to the minimization of the organs-at-risk dose and maximization of survival fraction (SF).
resultsThe new IMPT method with TV and L1 regularization was validated in comparison with the conventional IMPT method for pMBRT in several clinical cases. The results show that TVL1 provided larger PVDR and SF than the conventional IMPT method for biological sparing of normal tissues, with preserved plan quality in terms of physical dose distribution.
conclusionsA new spatially fractionated IMPT treatment planning method was developed for pMBRT that can optimize and improve normal-tissue PVDR and SF by incorporating TV and L1 dose regularization with properly chosen regularization parameters into IMPT.
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