Evidence map›Paper›PMID 36155070›Full record

ArticleAntiviral research2022

Repurposing of HIV/HCV protease inhibitors against SARS-CoV-2 3CL

Ling Ma, Quanjie Li, Yongli Xie, Jianyuan Zhao, Dongrong Yi, Saisai Guo, Fei Guo, Jing Wang, Long Yang, Shan Cen

Open access · greenAbstract read
In one paragraph

Article in Antiviral research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Identification of Darunavir Derivatives for Inhibition of SARS-CoV-2 3CLInternational journal of molecular sciences · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ling MaInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China.
Quanjie LiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China.
Yongli XieInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China.
Jianyuan ZhaoInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China.
Dongrong YiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China.
Saisai GuoInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China.
Fei GuoInstitute of Pathogen Biology, Chinese Academy of Medical Science, Beijing, China.
Jing WangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China. Electronic address: jingwang@imb.pumc.edu.cn.
Long YangSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. Electronic address: longyangrich@hotmail.com.
Shan CenInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China. Electronic address: shancen@imb.pumc.edu.cn.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNTianjin University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen that caused the global COVID-19 outbreak. The 3C-like protease (3CL

Indexed as

COVID-19 Drug TreatmentHepatitis CHIV InfectionsHIV Protease InhibitorsAntiviral AgentsCoronavirus 3C ProteasesCysteine EndopeptidasesDrug RepositioningHumansProtease InhibitorsReproducibility of ResultsSARS-CoV-2SimeprevirAntiviral AgentsCoronavirus 3C ProteasesCysteine EndopeptidasesHIV Protease InhibitorsProtease InhibitorsSimeprevirAnti-coronavirus drugProteaseScreening assaySevere acute respiratory syndrome coronavirus 2

Identifiers

PMID36155070
PMCPMC9499987
OpenAlexW4296894926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.