Evidence map›Paper›PMID 36154490›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2022

Impaired hemodynamic response to exercise in patients with peripheral artery disease: evidence of a link to inflammation and oxidative stress.

Jesse C Craig, Corey R Hart, Gwenael Layec, Oh Sung Kwon, Russell S Richardson, Joel D Trinity

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. The Role of Home-Based Exercise in the Management of Peripheral Artery Disease.Current treatment options in cardiovascular medicine · 2026
    Article
  3. Article
  4. Article
  5. Bradykinin 2 receptors contribute to the exaggerated exercise pressor reflex in a rat model of simulated peripheral artery disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jesse C CraigDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah.ORCID 0000-0001-5959-4139
Corey R HartGeriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Salt Lake City, Utah.
Gwenael LayecDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah.ORCID 0000-0002-5029-2457
Oh Sung KwonDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah.ORCID 0000-0002-9929-6774
Russell S RichardsonDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah.
Joel D TrinityDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah.ORCID 0000-0001-8271-6536
University of Utah · USUniversity of Connecticut · US

Funding

TRAINING IN CARDIOVASCULAR RESEARCHT32HL007576 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos, Robin M Shaw · 1985 to 2026
$10.6M
Tissue Imaging, Biochemistry and MorphologyP01HL091830 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WAGNER, PETER D · 2009 to 2013
$10.1M
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction during DisuseR01HL142603 · NHLBI · UNIVERSITY OF UTAH · PI TRINITY, JOEL DOUGLAS · 2019 to 2023
$2.9M
Cardiovasomobility Research Training ProgramT32HL139451 · NHLBI · UNIVERSITY OF UTAH · PI SUPIANO, MARK A, WRAY, D. WALTER · 2018 to 2022
$1.4M
Nitric oxide coupling and BH4 availability roles in muscle dysfunction with COPDK99HL125756 · NHLBI · UNIVERSITY OF UTAH · PI LAYEC, GWENAEL · 2015 to 2016
$300k
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction during DisuseI01CX001999 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI TRINITY, JOEL DOUGLAS · 2019 to 2023
–
Understanding the Exercise-Hypertension Paradox: Implication for RehabilitationIK2RX001215 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI TRINITY, JOEL DOUGLAS · 2014 to 2018
–
CSRD VA I01 CX001999NHLBI NIH HHS K99 HL125756NHLBI NIH HHS P01 HL091830NHLBI NIH HHS R01 HL142603NHLBI NIH HHS T32 HL007576NHLBI NIH HHS T32 HL139451RRD VA IK2 RX001215
6 · The paper itself

Abstract

An exaggerated mean arterial blood pressure (MAP) response to exercise in patients with peripheral artery disease (PAD), likely driven by inflammation and oxidative stress and, perhaps, required to achieve an adequate blood flow response, is well described. However, the blood flow response to exercise in patients with PAD actually remains equivocal. Therefore, eight patients with PAD and eight healthy controls completed 3 min of plantar flexion exercise at both an absolute work rate (WR) (2.7 W, to evaluate blood flow) and a relative intensity (40%WR

Indexed as

ExerciseInflammationOxidative StressPeripheral Arterial DiseaseArterial PressureHemodynamicsHumansInterleukin-6Muscle ProteinsMuscle, SkeletalRegional Blood FlowInterleukin-6Muscle Proteinsblood flowexercise pressor responseperipheral vascular disease

Identifiers

PMID36154490
PMCPMC9602942
OpenAlexW4297221545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.