Evidence map›Paper›PMID 36154489›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2022

Fatty acid amide hydrolase activity in the dorsal periaqueductal gray attenuates neuropathic pain and associated dysautonomia.

Victoria Woyach, Katherine Sherman, Cecilia J Hillard, Francis A Hopp, Quinn H Hogan, Caron Dean

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Victoria WoyachDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Katherine ShermanResearch Service, Zablocki Veterans Affairs Medical Center, Milwaukee Wisconsin.
Cecilia J HillardDepartment of Pharmacology and Toxicology and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
Francis A HoppResearch Service, Zablocki Veterans Affairs Medical Center, Milwaukee Wisconsin.
Quinn H HoganDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Caron DeanDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0002-5252-504X
Medical College of Wisconsin · USMilwaukee VA Medical Center · US

Funding

Endogenous cannabinoid signaling in the development of chronic neuropathic painI01RX002747 · VA · CLEMENT J. ZABLOCKI VA MEDICAL CENTER · PI DEAN-BERNHOFT, CARON · 2019 to 2023
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RRD VA I01 RX002747
6 · The paper itself

Abstract

The complexity of neuropathic pain and its associated comorbidities, including dysautonomia, make it difficult to treat. Overlap of anatomical regions and pharmacology of sympathosensory systems in the central nervous system (CNS) provide targets for novel treatment strategies. The dorsal periaqueductal gray (dPAG) is an integral component of both the descending pain modulation system and the acute stress response and is critically involved in both analgesia and the regulation of sympathetic activity. Local manipulation of the endocannabinoid signaling system holds great promise to provide analgesia without excessive adverse effects and also influence autonomic output. Inhibition of fatty acid amide hydrolase (FAAH) increases brain concentrations of the endocannabinoid

Indexed as

NeuralgiaPrimary DysautonomiasAmidohydrolasesAnimalsEndocannabinoidsFatty Acid Amide HydrolasesFemaleHyperalgesiaMalePeriaqueductal GrayPolyunsaturated AlkamidesRatsReceptor, Cannabinoid, CB1AmidohydrolasesEndocannabinoidsFatty Acid Amide HydrolasesPolyunsaturated AlkamidesReceptor, Cannabinoid, CB1endocannabinoidshyperalgesiaPF-3845spared nerve injuryURB597

Identifiers

PMID36154489
PMCPMC9639763
OpenAlexW4297238548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.