ArticleMicrobiology spectrum2022
Emergence of Extensively Drug-Resistant ST170 Citrobacter portucalensis with Plasmids pK218-KPC, pK218-NDM, and pK218-SHV from a Tertiary Hospital, China.
Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 8 citations in OpenAlex.
- Global spread and evolution of KPC-2 and NDM-1-producing Gram-negative bacteria.Science China. Life sciences · 2026Article
- Genomic landscape ofApplied and environmental microbiology · 2026Article
- Evolution and transmission landscape of the staphylococcalFrontiers in microbiology · 2026Article
- Characterization of NDM-4-ProducingInfection and drug resistance · 2026Article
- Optimal treatment of Imipenem and meropenem against bloodstream infections caused by the Citrobacter spp.BMC infectious diseases · 2025Article
- A novel clinical metaproteomics workflow enables bioinformatic analysis of host-microbe dynamics in disease.mSphere · 2024Article
- Prevalence of ST1049-KL5 carbapenem-resistant Klebsiella pneumoniae with a blaCommunications biology · 2024Article
- Emergence of an Extensive Drug ResistantInfection and drug resistance · 2024Article
- Convergence of plasmid-mediated Colistin and Tigecycline resistance inFrontiers in microbiology · 2023Article
- A brief insight intoFrontiers in antibiotics · 2023Review
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study is to characterize the molecular mechanism of a clinical carbapenem-resistant Citrobacter portucalensis strain K218, which coproduces KPC and NDM carbapenemases. K218 was isolated from a patient's blood sample in a Chinese tertiary hospital. Carbapenemases were detected by the immunocolloidal gold technique. The MIC values were determined by VITEK2. Whole-genome sequencing was performed on K218 and sequence data were analyzed using phylogenetics and extensive genomic comparison. This study reveals that K218 contains a single 5.08 Mb chromosome (51.8% GC content) and four plasmids, pK218-KPC (106 Kb), pK218-NDM (111 Kb), pK218-SHV (191 Kb), and pK218-NR (5 Kb). Twenty-nine types of antibiotic resistance genes were carried on K218, including
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