Evidence map›Paper›PMID 36154055›Full record

ArticleJournal of medicinal chemistry2022

Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases.

Alaa Alhayek, Ahmed S Abdelsamie, Esther Schönauer, Virgyl Camberlein, Evelyn Hutterer, Gernot Posselt, Jamil Serwanja, Constantin Blöchl, Christian G Huber, Jörg Haupenthal and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Alaa AlhayekHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.
Ahmed S AbdelsamieHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.
Esther SchönauerDepartment of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria.
Virgyl CamberleinHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.
Evelyn HuttererDepartment of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria.ORCID 0000-0001-8622-4758
Gernot PosseltDepartment of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria.
Jamil SerwanjaDepartment of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria.
Constantin BlöchlDepartment of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria.
Christian G HuberDepartment of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria.
Jörg HaupenthalHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.
Hans BrandstetterDepartment of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria.
Silja WesslerDepartment of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria.
Anna K H HirschHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.ORCID 0000-0001-8734-4663
University of Salzburg · ATHelmholtz Institute for Pharmaceutical Research Saarland · DENational Research Centre · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In view of the worldwide antimicrobial resistance (AMR) threat, new bacterial targets and anti-infective agents are needed. Since important roles in bacterial pathogenesis have been demonstrated for the collagenase H and G (ColH and ColG) from

Indexed as

Matrix Metalloproteinase InhibitorsMicrobial CollagenaseCollagenasesDiphosphonatesHathewaya histolyticaCollagenasesDiphosphonatesMatrix Metalloproteinase InhibitorsMicrobial Collagenase

Identifiers

PMID36154055
PMCPMC9574867
OpenAlexW4297226849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.