ArticleAsian journal of andrology
Bisphenol A induces testicular oxidative stress in mice leading to ferroptosis.
Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- The role of iron in normal and impaired testicular function.Andrology · 2026Review
- Berberine nanoemulsion against nephrotoxicity induced by bisphenol a in rats during pre-puberty stage.Toxicology reports · 2026Article
- Transgenerational exposure to plastics-derived endocrine-disrupting bisphenol A and its analogs on male infertility: impact of gut dysbiosis and epigenetic regulation.Frontiers in endocrinology · 2026Review
- Ginsenoside Rg1 alleviated testicular and sperm damage in rats exposed to bisphenol A.Biochemistry and biophysics reports · 2025Article
- Zinc Attenuates Bisphenol A-Induced Reproductive Toxicity in Male Mice by Inhibiting Ferroptosis and Apoptosis Through Improving Zinc Homeostasis.Biological trace element research · 2025Article
- Environmental pollutant Di-(2-ethylhexyl) phthalate induces asthenozoospermia: new insights from network toxicology.Molecular diversity · 2025Article
- Exposure of pregnant and lactating parental mice to aflatoxin BArchives of toxicology · 2025Article
- Interlinkage between inflammation, oxidative stress, and endoplasmic reticulum stress in bisphenols-induced testicular steroidogenesis disturbance: A mini review.International journal of reproductive biomedicine · 2025Review
- Acupuncture mediates the "gut-testis axis" to improve asthenozoospermia.Frontiers in endocrinology · 2025Article
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- Metabolomics reveals that ferroptosis participates in bisphenol A-induced testicular injury.Heliyon · 2024Article
- Cloning and Characterization of YakAnimals : an open access journal from MDPI · 2023Article
- Emerging roles of ferroptosis in male reproductive diseases.Cell death discovery · 2023Review
- Ferritin heavy chain participated in ameliorating 3-nitropropionic acid-induced oxidative stress and apoptosis of goose follicular granulosa cells.Poultry science · 2023Article
- Review
- Review of the Role of Ferroptosis in Testicular Function.Nutrients · 2022Review
- Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-Κb-Activated Inducible Nitric Oxide Synthase: First Demonstration of an Intricate Mechanism.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bisphenol A is a common environmental factor and endocrine disruptor that exerts a negative impact on male reproductive ability. By exploring bisphenol A-induced testicular cell death using the Institute of Cancer Research (ICR) mouse model, we found that a ferroptosis phenomenon may exist. Mice were divided into six groups and administered different doses of bisphenol A via intragastric gavage once daily for 45 consecutive days. Serum was then collected to determine the levels of superoxide dismutase and malondialdehyde. Epididymal sperm was also collected for semen analysis, and testicular tissue was collected for ferritin content determination, electron microscope observation of mitochondrial morphology, immunohistochemistry, real-time quantitative polymerase chain reaction, and western blot analysis. Exposure to bisphenol A was found to decrease sperm quality and cause oxidative damage, iron accumulation, and mitochondrial damage in the testes of mice. In addition, bisphenol A was confirmed to affect the expression of the ferroptosis-related genes, glutathione peroxidase 4 (GPX4), ferritin heavy chain 1 (FTH1), cyclooxygenase 2 (COX2), and acyl-CoA synthetase 4 (ACSL4) in mouse testicular tissues. Accordingly, we speculate that bisphenol A induces oxidative stress, which leads to the ferroptosis of testicular cells. Overall, the inhibition of ferroptosis may be a potential strategy to reduce male reproductive toxicity caused by bisphenol A.
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Registered trials
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