Evidence map›Paper›PMID 36153823›Full record

ArticleAdvanced healthcare materials2022

Pharmacokinetics of Intramuscularly Administered Thermoresponsive Polymers.

Ondřej Groborz, Kristýna Kolouchová, Jan Pankrác, Peter Keša, Jan Kadlec, Tereza Krunclová, Aneta Pierzynová, Jaromír Šrámek, Mária Hovořáková, Linda Dalecká and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Digital Light Processing ofMaterials (Basel, Switzerland) · 2024
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Ondřej GroborzInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského náměstí 2, Prague 6, Prague, 162 06, Czech Republic.ORCID 0000-0002-3164-6168
Kristýna KolouchováInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského náměstí 2, Prague 6, Prague, 162 06, Czech Republic.ORCID 0000-0002-8874-8632
Jan PankrácCenter for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Salmovská 3, Prague 2, Prague, 120 00, Czech Republic.ORCID 0000-0002-9574-1391
Peter KešaCenter for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Salmovská 3, Prague 2, Prague, 120 00, Czech Republic.ORCID 0000-0002-3890-5409
Jan KadlecWeizmann Institute of Science, Department of Brain Sciences, Rehovot, 7610001, Israel.ORCID 0000-0003-2477-3633
Tereza KrunclováInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského náměstí 2, Prague 6, Prague, 162 06, Czech Republic.ORCID 0000-0002-5232-8214
Aneta PierzynováInstitute of Histology and Embryology, First Faculty of Medicine, Charles University, Albertov 4, Prague 2, Prague, 128 00, Czech Republic.ORCID 0000-0003-3770-782X
Jaromír ŠrámekInstitute of Histology and Embryology, First Faculty of Medicine, Charles University, Albertov 4, Prague 2, Prague, 128 00, Czech Republic.ORCID 0000-0003-0287-8936
Mária HovořákováInstitute of Histology and Embryology, First Faculty of Medicine, Charles University, Albertov 4, Prague 2, Prague, 128 00, Czech Republic.ORCID 0000-0002-6346-6671
Linda DaleckáInstitute of Histology and Embryology, First Faculty of Medicine, Charles University, Albertov 4, Prague 2, Prague, 128 00, Czech Republic.ORCID 0000-0003-0512-2122
Zuzana PavlíkováInstitute of Histology and Embryology, First Faculty of Medicine, Charles University, Albertov 4, Prague 2, Prague, 128 00, Czech Republic.ORCID 0000-0001-9890-3272
Petr MatoušCenter for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Salmovská 3, Prague 2, Prague, 120 00, Czech Republic.
Petr PáralCenter for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Salmovská 3, Prague 2, Prague, 120 00, Czech Republic.ORCID 0000-0003-2308-9688
Lenka LoukotováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo náměstí 542, Prague 6, Prague, 160 00, Czech Republic.ORCID 0000-0002-8087-1425
Pavel ŠvecInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo náměstí 542, Prague 6, Prague, 160 00, Czech Republic.ORCID 0000-0002-6604-2815
Hynek BenešInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského náměstí 2, Prague 6, Prague, 162 06, Czech Republic.ORCID 0000-0002-6861-1997
Lubomír ŠtěpánekInstitute of Biophysics and Informatics, Charles University, First Faculty of Medicine, Salmovská 1, Prague 2, Prague, 120 00, Czech Republic.
David DunlopInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo náměstí 542, Prague 6, Prague, 160 00, Czech Republic.ORCID 0000-0001-5351-7036
Carlos V MeloDepartment of Physical and Macromolecular Chemistry, Faculty of Sciences, Charles University, Hlavova 8, Prague 2, Prague, 128 00, Czech Republic.
Luděk ŠefcCenter for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Salmovská 3, Prague 2, Prague, 120 00, Czech Republic.ORCID 0000-0003-2846-220X
Tomáš SlaninaInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo náměstí 542, Prague 6, Prague, 160 00, Czech Republic.ORCID 0000-0001-8092-7268
Jiří BenešInstitute of Biophysics and Informatics, Charles University, First Faculty of Medicine, Salmovská 1, Prague 2, Prague, 120 00, Czech Republic.ORCID 0000-0003-0286-0138
Sandra Van VlierbergheDepartment of Organic and Macromolecular Chemistry, Centre of Macromolecular Chemistry, Ghent University, Krijgslaan 281-S4, Ghent, 9000, Belgium.ORCID 0000-0001-7688-1682
Richard HoogenboomDepartment of Organic and Macromolecular Chemistry, Centre of Macromolecular Chemistry, Ghent University, Krijgslaan 281-S4, Ghent, 9000, Belgium.ORCID 0000-0001-7398-2058
Martin HrubýInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského náměstí 2, Prague 6, Prague, 162 06, Czech Republic.ORCID 0000-0002-5075-261X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aqueous solutions of some polymers exhibit a lower critical solution temperature (LCST); that is, they form phase-separated aggregates when heated above a threshold temperature. Such polymers found many promising (bio)medical applications, including in situ thermogelling with controlled drug release, polymer-supported radiotherapy (brachytherapy), immunotherapy, and wound dressing, among others. Yet, despite the extensive research on medicinal applications of thermoresponsive polymers, their biodistribution and fate after administration remained unknown. Thus, herein, they studied the pharmacokinetics of four different thermoresponsive polyacrylamides after intramuscular administration in mice. In vivo, these thermoresponsive polymers formed depots that subsequently dissolved with a two-phase kinetics (depot maturation, slow redissolution) with half-lives 2 weeks to 5 months, as depot vitrification prolonged their half-lives. Additionally, the decrease of T

Indexed as

PolymersWaterAnimalsDrug LiberationMiceTemperatureTissue DistributionPolymersWaterbiodistributionLCSTpoly(2,2-difluoroethyl)acrylamidepolyacrylamidepoly(N-acryloylpyrolidine)poly(N-isopropylacrylamide)poly(N,N-diethylacrylamide)rational polymer design

Identifiers

PMID36153823
PMCPMC11468617

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.