Evidence map›Paper›PMID 36153665›Full record

SynthesisJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2022

Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review.

Janice L Pasieka, Kelly Wentworth, Caitlin T Yeo, Serge Cremers, David Dempster, Seiji Fukumoto, Ravinder Goswami, Pascal Houillier, Michael A Levine, Jesse D Pasternak and 3 more

2 registry-linked trialsOpen access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07299838 completednot on this mapstarted 2024, after this paper: background citation

Real-World Data for Effectiveness and Safety of Palopegteriparatide in Patients With Chronic Hypoparathyroidism in Greece

TypeobservationalSponsorNational and Kapodistrian University of AthensRan2024 to 2025Enrolled90ConditionsHypoparathyroidism
NCT07416149 narecruitingnot on this mapstarted 2025, after this paper: background citation

Reducing Post-operative Hypoparathyroidism With Probe-based Near Infrared Autofluorescence (NIRAF)- Assisted Total Thyroidectomy Versus Conventional Total Thyroidectomy, a Randomized-controlled Trial

TypeinterventionalSponsorThe University of Hong KongRan2025 to 2028Enrolled210ConditionsHypocalcemia, Parathyroid, Hypoparathyroidism Post-surgical, Total ThyroidectomyArmsPTeye™ parathyroid detection system
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 6 countries.

Janice L PasiekaClinical Professor of Surgery and Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID 0000-0003-2753-4988
Kelly WentworthAssistant Adjunct Professor of Medicine, University of California, San Francisco, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA.ORCID 0000-0002-3711-1121
Caitlin T YeoClinical Lecturer of Surgery and Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID 0000-0002-3517-0910
Serge CremersAssociate Professor of Pathology and Cell Biology and Medicine, Vagelos College of Physicians and Surgeons of Columbia University, New York, NY, USA.ORCID 0000-0002-6800-5532
David DempsterProfessor of Clinical Pathology and Cell Biology, Vagelos College of Physicians and Surgeons of Columbia University, New York, NY, USA.ORCID 0000-0002-2262-4039
Seiji FukumotoSpecially Appointed Professor, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.ORCID 0000-0003-3610-3469
Ravinder GoswamiProfessor, Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.ORCID 0000-0002-3097-5074
Pascal HouillierDépartement de Physiologie, Professor of Physiology, Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.ORCID 0000-0003-4953-6917
Michael A LevineProfessor Emeritus of Pediatrics and Medicine, University of Pennsylvania, Director, Center for Bone Health, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-0036-7809
Jesse D PasternakEndocrine Surgery Section Head, Division of General Surgery, Department of Surgery, University Health Network, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-4342-9080
Nancy D PerrierProfessor of Surgery, University of Texas MD Anderson Cancer Center, Department of Surgical Oncology, Section of Surgical Endocrinology, Houston, TX, USA.ORCID 0000-0001-5933-1005
Antonio Sitges-SerraEmeritus Professor, Universitat Autònoma de Barcelona, Endocrine Surgery, Hospital del Mar, Barcelona, Spain.ORCID 0000-0003-0355-7325
Dolores M ShobackProfessor of Medicine, University of California, San Francisco, Endocrine Research Unit, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.ORCID 0000-0003-2936-4468
Columbia University · USUniversity of Calgary · CAAll India Institute of Medical Sciences · INChildren's Hospital of Philadelphia · USInserm · FRSan Francisco General Hospital · USSan Francisco VA Medical Center · USThe University of Texas MD Anderson Cancer Center · USTokushima University · JPUniversitat Autònoma de Barcelona · ESUniversity Health Network · CA

Funding

Repurposing rifampin to reduce elevated levels of blood and urine calcium in patients with inactivating mutations of CYP24A1R01DK112955 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI Michael A. Levine, David R Weber · 2017 to 2026
$5.1M
The Role of GCM2 in Parathyroid Gland HomeostasisR01DK079970 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI LEVINE, MICHAEL A. · 2009 to 2015
$3.2M
NIDDK NIH HHS R01 DK079970NIDDK NIH HHS R01 DK112955
6 · The paper itself

Abstract

The approach utilized a systematic review of the medical literature executed with specifically designed criteria that focused on the etiologies and pathogenesis of hypoparathyroidism. Enhanced attention by endocrine surgeons to new knowledge about parathyroid gland viability are reviewed along with the role of intraoperative parathyroid hormone (ioPTH) monitoring during and after neck surgery. Nonsurgical etiologies account for a significant proportion of cases of hypoparathyroidism (~25%), and among them, genetic etiologies are key. Given the pervasive nature of PTH deficiency across multiple organ systems, a detailed review of the skeletal, renal, neuromuscular, and ocular complications is provided. The burden of illness on affected patients and their caregivers contributes to reduced quality of life and social costs for this chronic endocrinopathy. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

Indexed as

HypoparathyroidismHumansParathyroid GlandsParathyroid HormoneQuality of LifeParathyroid HormoneCELL/TISSUE SIGNALINGDISORDERS OF CALCIUM/PHOSPHATE METABOLISMENDOCRINE PATHWAYSHORMONE REPLACEMENT/RECEPTOR MODULATORSPARATHYROID-RELATED DISORDERSPTH/VIT D/FGF23THERAPEUTICS

Identifiers

PMID36153665
PMCPMC10364481
OpenAlexW4297912724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.