Evidence map›Paper›PMID 36153530›Full record

ArticleTrials2022

Optimal target blood pressure in elderly with septic shock (OPTPRESS) trial: study protocol for a randomized controlled trial.

Akira Endo, Kazuma Yamakawa, Takashi Tagami, Yutaka Umemura, Kyosuke Takahashi, Hiroki Nagasawa, Yuichi Araki, Mitsuaki Kojima, Toshiki Sera, Masayuki Yagi and 20 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 1 country.

Akira EndoTrauma and Acute Critical Care Center, Tokyo Medical and Dental University Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan. eraeaccm@tmd.ac.jp.ORCID http://orcid.org/0000-0002-5967-0776
Kazuma YamakawaDepartment of Emergency Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki, Osaka, Japan.
Takashi TagamiDepartment of Emergency and Critical Care Medicine, Nippon Medical School Musashikosugi Hospital, 1-396 Kosugimachi, Nakahara-ku, Kawasaki, Kanagawa, Japan.
Yutaka UmemuraDivision of Trauma and Surgical Critical Care, Osaka General Medical Center, 3-1-56 Bandai-Higashi, Sumiyoshi, Osaka, 558-8558, Japan.
Kyosuke TakahashiEmergency and Critical Care Center, Hyogo Prefectural Nishinomiya Hospital, 13-9, Rokutanjicho, Nishinomiya City, Hyogo, Japan.
Hiroki NagasawaDepartment of Acute Critical Care Medicine, Shizuoka Hospital, Juntendo University, 1129 Nagaoka, Izunokuni City, Shizuoka, Japan.
Yuichi ArakiDepartment of Acute Critical Care Medicine, Tsuchiura Kyodo General Hospital, 4-1-1 Otsuno, Tsuchiura, Ibaraki, Japan.
Mitsuaki KojimaEmergency and Critical Care Medicine, Tokyo Women's Medical University Adachi Medical Center, 4-33-1 Kohoku, Adachi-ku, Tokyo, Japan.
Toshiki SeraCritical Care Medical Center, Hiroshima Prefectural Hospital, 1-5-54 Ujinakanda, Minami-ku, Hiroshima, Japan.
Masayuki YagiEmergency Medicine and Acute Care Surgery, Matsudo City General Hospital, 993-1 Sendabori, Matsudo-shi, Chiba, Japan.
Ryo YamamotoDepartment of Emergency and Critical Care Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan.
Jiro TakahashiDepartment of Acute Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, Japan.
Masaki NakaneDepartment of Emergency and Critical Care Medicine, Yamagata University Hospital, 2-2-2 Iida-nishi, Yamagata, Japan.
Chikashi TakedaDepartment of Anesthesia, Kyoto University Hospital, Shogoin Kawaharacho54, Sakyo-ku, Kyoto, Japan.
Chihiro NaritaDepartment of Emergency Medicine, Shizuoka General Hospital, 4-27-1 Kitaando, Aoiku, Shizuoka, Japan.
Satoshi KazumaDepartment of Intensive Care Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido, Japan.
Hiroko OkuraDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, Japan.
Hiroyuki TakahashiEmergency and Critical Care Medical Center, Teine Keijinkai Hospital, 1-jo 12-chome, Maeda, Teine-ku, Sapporo, Japan.
Takeshi WadaDepartment of Anesthesiology and Critical Care Medicine, Division of Acute and Critical Care Medicine, Hokkaido University Faculty of Medicine, N15, W7, Kita-ku, Sapporo, Japan.
Shu TaharaDepartment of Emergency Medicine, Sunagawa City Medical Center, 3-chome1-1 Nishi 4-jo Kita, Sunagawa-shi, Hokkaido, Japan.
Ayaka MatsuokaDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga City, Saga, Japan.
Todani MasakiAdvanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, Japan.
Atsushi ShiraishiEmergency and Trauma Center, Kameda Medical Center, 929 Higashicho, Kamogawa, Chiba, Japan.
Keiichiro ShimoyamaDepartment of Emergency and Critical Care Medicine, Tokyo Medical University, 6-7-1, Nisi-Shinjuku, Shinjuku-Ku, Tokyo, 160-0023, Japan.
Yuta YokokawaDivision of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, Sendai, Miyagi, Japan.
Rintaro NakamuraDepartment of Emergency Medicine, Ibaraki Seinan Medical Center Hospital, 2190 Sakai, Sashima, Ibaraki, Japan.
Hisako SageshimaDepartment of Emergency Medicine, Sapporo City General Hospital, 13-1-1, Kita-11-jonishi, Chuo-ku, Hokkaido, Japan.
Yuichiro YanagidaDepartment of Emergency, Fukuoka City Hospital, 13-1 Yoshitukahoncho, Hakata-ku, Fukuoka, Japan.
Kunihiko TakahashiM&D Data Science Center, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan.
Yasuhiro OtomoTrauma and Acute Critical Care Center, Tokyo Medical and Dental University Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan.
Tokyo Medical and Dental University · JPFukuoka City Hospital · JPFukuoka University · JPHiroshima Prefectural Hospital · JPHokkaido University · JPJuntendo University Shizuoka Hospital · JPKameda Medical Center · JPKawasaki Medical School · JPKeio University · JPKyoto University Hospital · JPMatsudo City Hospital · JPNippon Medical School · JPOsaka Prefectural Medical Center · JPOsaka University of Pharmaceutical Sciences · JPSaga University · JPSapporo City General Hospital · JPSapporo Medical University · JPShizuoka General Hospital · JPSunagawa City Medical Center · JPTeine Keijinkai Hospital · JP

Funding

Japan Society for the Promotion of Science JP21H03197
6 · The paper itself

Abstract

backgroundHemodynamic stabilization is a core component in the resuscitation of septic shock. However, the optimal target blood pressure remains debatable. Previous randomized controlled trials suggested that uniformly adopting a target mean arterial pressure (MAP) higher than 65 mmHg for all adult septic shock patients would not be beneficial; however, it has also been proposed that higher target MAP may be beneficial for elderly patients, especially those with arteriosclerosis.

methodsA multicenter, pragmatic single-blind randomized controlled trial will be conducted to compare target MAP of 80-85 mmHg (high-target) and 65-70 mmHg (control) in the resuscitation of septic shock patients admitted to 28 hospitals in Japan. Patients with septic shock aged ≥65 years are randomly assigned to the high-target or control groups. The target MAP shall be maintained for 72 h after randomization or until vasopressors are no longer needed to improve patients' condition. To minimize the adverse effects related to catecholamines, if norepinephrine dose of ≥ 0.1 μg/kg/min is needed to maintain the target MAP, vasopressin will be initiated. Other therapeutic approaches, including fluid administration, hydrocortisone use, and antibiotic choice, will be determined by the physician in charge based on the latest clinical guidelines. The primary outcome is all-cause mortality at 90 days after randomization. DISCUSSION: The result of this trial will provide great insight on the resuscitation strategy for septic shock in the era of global aged society. Also, it will provide the better understanding on the importance of individualized treatment strategy in hemodynamic management in critically ill patients.

trial registrationUMIN Clinical Trials Registry; UMIN000041775. Registered 13 September 2020.

Indexed as

Shock, SepticAdultAgedAnti-Bacterial AgentsBlood PressureCatecholaminesHumansHydrocortisoneMulticenter Studies as TopicNorepinephrinePragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicSingle-Blind MethodVasoconstrictor AgentsVasopressinsAnti-Bacterial AgentsCatecholaminesHydrocortisoneNorepinephrineVasoconstrictor AgentsVasopressinsArterial pressureGeriatricsHypotensionSepsisVasoconstrictor agents

Identifiers

PMID36153530
PMCPMC9509562
OpenAlexW4296954435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.