Evidence map›Paper›PMID 36153526›Full record

ArticleJournal of nanobiotechnology2022

A bimodal type of AgPd Plasmonic Blackbody Nanozyme with boosted catalytic efficacy and synergized photothermal therapy for efficacious tumor treatment in the second biological window.

Tao Jia, Dan Li, Jiarui Du, Xikui Fang, Valeriy Gerasimov, Hans Ågren, Guanying Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tao JiaMIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & State Key Laboratory of Urban Water Resource and Environment & Key Laboratory of Micro-systems and Micro-tructures Ministry of Education, Harbin Institute of Technology, Harbin, 150001, People's Republic of China.
Dan LiMIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & State Key Laboratory of Urban Water Resource and Environment & Key Laboratory of Micro-systems and Micro-tructures Ministry of Education, Harbin Institute of Technology, Harbin, 150001, People's Republic of China.
Jiarui DuMIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & State Key Laboratory of Urban Water Resource and Environment & Key Laboratory of Micro-systems and Micro-tructures Ministry of Education, Harbin Institute of Technology, Harbin, 150001, People's Republic of China.
Xikui FangMIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & State Key Laboratory of Urban Water Resource and Environment & Key Laboratory of Micro-systems and Micro-tructures Ministry of Education, Harbin Institute of Technology, Harbin, 150001, People's Republic of China.
Valeriy GerasimovInternational Research Center of Spectroscopy and Quantum Chemistry, Siberian Federal University, Krasnoyarsk, 660041, Russia.
Hans ÅgrenMIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & State Key Laboratory of Urban Water Resource and Environment & Key Laboratory of Micro-systems and Micro-tructures Ministry of Education, Harbin Institute of Technology, Harbin, 150001, People's Republic of China.
Guanying ChenMIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & State Key Laboratory of Urban Water Resource and Environment & Key Laboratory of Micro-systems and Micro-tructures Ministry of Education, Harbin Institute of Technology, Harbin, 150001, People's Republic of China. chenguanying@hit.edu.cn.

Funding

National Natural Science Foundation of China 51972084Open Fund of the State Key Laboratory of Integrated Optoelectronics IOSKL2019KF04State Key Laboratory of Urban Water Resource and Environment (Harbin Institute of Technology) (No. 2020DX10)the Fundamental Research Funds for the Central Universities, China AUGA5710052614Young Scientist Workshop (Harbin Institute of Technology) AUGA5710094420
6 · The paper itself

Abstract

Nanozymes are promising for precise cancer treatment, but are typically limited in terms of the low catalytic efficiency and the complexity in tumor microenvironment (TME). Herein, we describe a bimodal type of AgPd plasmonic blackbody (AgPd PB) nanozyme of compact sizes (< 30 nm), which presents not only boosted enzyme efficacy but also efficient photothermal therapy (PTT) for synergized therapy through tissue-penetrating light in the second biological window (1000-1700 nm). The synthesized hyperbranched AgPd PB nanozymes possess intense and broadband localized surface plasmonic resonance absorption of 400-1300 nm, entailing prominent photothermal efficiency (η = 45.1% at 1064 nm) for PTT. Importantly, PTT was found to significantly boost the nanozyme efficacy of both catalase (CAT) and peroxidase (POD) processes, which correspondingly decompose H

Indexed as

NanoparticlesNeoplasmsCatalaseCell Line, TumorHeat-Shock ProteinsHumansHydrogen PeroxidePhotothermal TherapyTumor MicroenvironmentCatalaseHeat-Shock ProteinsHydrogen PeroxideBlack bodyNanozymePlasmonicTheranosticsTumor microenvironment

Identifiers

PMID36153526
PMCPMC9509650

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.