Evidence map›Paper›PMID 36153433›Full record

ArticleOphthalmology and therapy2022

Optical Coherence Tomography-Based Choroidal Structural Analysis and Vascularity Index in Best Vitelliform Macular Dystrophy.

Xin Wei, Rupak Roy, Kumar Saurabh, Parveen Sen, Muna Bhende, Komal Shelke, Lucia Finocchio, Andrea Sodi, Gianni Virgili, Alessandro Invernizzi and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 5 countries.

Xin WeiNational Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, 308433, Singapore.
Rupak RoySankara Nethralaya, Kolkata, India.
Kumar SaurabhSankara Nethralaya, Kolkata, India.
Parveen SenShri Bhagwan Mahavir Vitreoretinal Service, Medical Research Foundation, Chennai, 600006, India.
Muna BhendeShri Bhagwan Mahavir Vitreoretinal Service, Medical Research Foundation, Chennai, 600006, India.
Komal ShelkeShri Bhagwan Mahavir Vitreoretinal Service, Medical Research Foundation, Chennai, 600006, India.
Lucia FinocchioDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Andrea SodiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Gianni VirgiliDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Alessandro InvernizziEye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco", Luigi Sacco Hospital, University of Milan, Milan, Italy.
Anna Paola SalvettiDepartment of Biomedical and Clinical Science "Luigi Sacco", Luigi Sacco Hospital, University of Milan, Milan, Italy.
Chitaranjan MishraTrilochan Netralaya, Sambalpur, Odisha, India.
Rupesh AgrawalNational Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, 308433, Singapore. rupeshttsh@gmail.com.ORCID http://orcid.org/0000-0002-6662-5850
University of Florence · ITSankara Nethralaya · INMoorfields Eye Hospital NHS Foundation Trust · GBTan Tock Seng Hospital · SGThe University of Sydney · AUUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study investigated choroidal structural changes on optical coherence tomography (OCT) using choroidal vascularity index (CVI) and choroidal thickness (CT) in patients with Best vitelliform macular dystrophy (BVMD).

methodsThis retrospective case control study included 78 patients with BVMD of different clinical stages and 242 age- and gender-matched healthy controls. Subfoveal OCT scans were analysed. Total choroidal area (TCA), luminal area (LA) and CT were measured after image segmentation and binarization. CVI, a novel marker for choroidal angioarchitecture, was defined as the ratio of LA to TCA. CVI and CT were compared between BVMD and control group, as well as among the BVMD subgroups.

resultsMean CVI was lower in eyes with BVMD (65.0 ± 3.5%) compared to that in control eyes (67.5 ± 3.9%) and this was statistically significant (p < 0.0001). There was no significant difference in subfoveal CT between BVMD (302.88 ± 81.68 μm) and control (309.31 ± 65.46 μm) eyes (p = 0.4799). In the subgroup analysis, all stages of BVMD showed lower CVI compared to control while SFCT remained similar. Within the BVMD subgroups, CVI and subfoveal CT did not differ significantly and both were not shown to be associated with visual acuity.

conclusionDecreased CVI was shown in eyes with BVMD compared to control eyes, while no significant difference in subfoveal CT was seen. CVI may be helpful in the understanding of choroidal pathology in BVMD.

Indexed as

Best vitelliform macular dystrophyChoroidChoroidal structural analysisChoroidal vascularity indexOptical coherence tomography

Identifiers

PMID36153433
PMCPMC9587204
OpenAlexW4296970818

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.